Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. (Q35875359)

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1 February 2020

title

Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection (English)

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1 February 2020

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1 February 2020

Gang Feng

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1 February 2020

Satish N Nadig

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1 February 2020

Liselotte Bäckdahl

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1 February 2020

Stephan Beck

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1 February 2020

Andrew Whatcott

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1 February 2020

Kathryn J Wood

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1 February 2020

Andrew Bushell

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1 February 2020

language of work or name

English

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publication date

1 May 2011

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Science Translational Medicine

1 February 2020

published in

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volume

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issue

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page(s)

83ra40

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Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells.

1 February 2020

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

11 July 2018

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11 July 2018

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Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

11 July 2018

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

11 July 2018

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Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression

11 July 2018

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11 July 2018

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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

11 July 2018

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Epigenetic control of the foxp3 locus in regulatory T cells

11 July 2018

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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

11 July 2018

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

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Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development

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T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine

11 July 2018

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

11 July 2018

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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

11 July 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

11 July 2018

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Control of regulatory T cell development by the transcription factor Foxp3

11 July 2018

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Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors

11 July 2018

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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24 September 2018

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24 September 2018

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CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

24 September 2018

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24 September 2018

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Foxp3-dependent programme of regulatory T-cell differentiation

24 September 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002099

The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality

21 January 2018

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12 December 2020

Regulation of interleukin 2 synthesis by cAMP in human T cells

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12 December 2020

CD3- and CD28-dependent induction of PDE7 required for T cell activation

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12 December 2020

CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation

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12 December 2020

GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function

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12 December 2020

Pyrosequencing protocol using a universal biotinylated primer for mutation detection and SNP genotyping

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12 December 2020

DNA methylation analysis by pyrosequencing

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Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

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12 December 2020

Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy

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12 December 2020

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

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12 December 2020

10.1126/SCITRANSLMED.3002099

Identifiers

DOI

1 reference

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1 February 2020

1 reference

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1 February 2020

PubMed publication ID

21593400

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21593400%20AND%20SRC:MED&resulttype=core&format=json