CD3-specific antibody-induced active tolerance: from bench to bedside (Q35058543)

6 August 2017

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title

CD3-specific antibody-induced active tolerance: from bench to bedside (English)

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6 August 2017

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Lucienne Chatenoud

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publication date

1 February 2003

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Nature Reviews Immunology

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

123-132

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Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

6 August 2017

cites work

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Selective reduction and proliferation of the CD4+ and CD8+ T cell subsets with bispecific monoclonal antibodies: evidence for inter-T cell-mediated cytolysis

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Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3.

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PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

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A humanized monovalent CD3 antibody which can activate homologous complement

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Systemic reaction to the anti-T-cell monoclonal antibody OKT3 in relation to serum levels of tumor necrosis factor and interferon-gamma [corrected]

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Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

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CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb

31 March 2020

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In vivo effects of IgA and IgG2a anti-CD3 isotype switch variants

31 March 2020

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The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

31 March 2020

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Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites

31 March 2020

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Reshaping human antibodies for therapy

31 March 2020

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Induction of tolerance by monoclonal antibody therapy

31 March 2020

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Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes

31 March 2020

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31 March 2020

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31 March 2020

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

31 March 2020

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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

31 March 2020

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31 March 2020

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31 March 2020

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Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

31 March 2020

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Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses

31 March 2020

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Reinduction of experimental allergic encephalomyelitis in convalescent Lewis rats with cyclophosphamide

31 March 2020

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31 March 2020

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Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer

31 March 2020

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

31 March 2020

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Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy

31 March 2020

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HuM291(Nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor

31 March 2020

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Perturbation of the T4 molecule transmits a negative signal to T cells

31 March 2020

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Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity

31 March 2020

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Treatment of acute renal allograft rejection with OKT3 monoclonal antibody

31 March 2020

1 reference

7 January 2021

Sequential therapy--a prospective randomized trial of MALG versus OKT3 for prophylactic immunosuppression in cadaver renal allograft recipients

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7 January 2021

The long-term effects of prophylactic OKT3 monoclonal antibody in cadaver kidney transplantation--a single-center, prospective, randomized study

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7 January 2021

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

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7 January 2021

Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody

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7 January 2021

Identifiers

DOI

10.1038/NRI1000

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Dimensions Publication ID

6 August 2017

1004399425

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