PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models (Q35858617)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Rakesh K Jain

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Bhushankumar Patel

1 reference

18 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

David P Kodack

1 reference

18 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

Sidra Mahmood

1 reference

18 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

Eugene Lifshits

1 reference

18 February 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

Helen Y Zou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Lars D Engstrom

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Qiuhua Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Melissa West

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Ruth W Tang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Hui Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Konstantinos Tsaparikos

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Jinwei Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Sergei Timofeevski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Dac M Dinh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Hieu Lam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Justine L Lam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Shinji Yamazaki

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Wenyue Hu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Rosa L Frias

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Justin F Gainor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Timothy Affolter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Patrick B Lappin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Hovhannes Gukasyan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Nathan Lee

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Shibing Deng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Ted W Johnson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Alice T Shaw

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Valeria R Fantin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Tod Smeal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

publication date

2 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

70-81

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

18 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4504786/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

First-line crizotinib versus chemotherapy in ALK-positive lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Patient-derived models of acquired resistance can identify effective drug combinations for cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung Cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Ceritinib in ALK-rearranged non-small-cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Long-lasting response to crizotinib in brain metastases due to EML4-ALK-rearranged non-small-cell lung cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

ALK in lung cancer: past, present, and future

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Mechanisms of acquired resistance to targeted cancer therapies.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Mechanisms of intrinsic and acquired resistance to kinase-targeted therapies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Acquired resistance to drugs targeting receptor tyrosine kinases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802).

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

ALK Inhibition for Non-Small Cell Lung Cancer: From Discovery to Therapy in Record Time

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Diversity of mechanism-based pharmacodynamic models

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Cancer. Addiction to oncogenes--the Achilles heal of cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Rapid response of brain metastasis to crizotinib in a patient with ALK rearrangement-positive non-small-cell lung cancer.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

Taking aim at ALK across the blood-brain barrier

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

High-dose pemetrexed in combination with high-dose crizotinib for the treatment of refractory CNS metastases in ALK-rearranged non-small-cell lung cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504786

10.1016/J.CCELL.2015.05.010

24 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

26144315

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26144315%20AND%20SRC:MED&resulttype=core&format=json