Patient-derived models of acquired resistance can identify effective drug combinations for cancer. (Q34447778)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394791%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Patient-derived models of acquired resistance can identify effective drug combinations for cancer (English)

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22 February 2020

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22 February 2020

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22 February 2020

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22 February 2020

Lecia V Sequist

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22 February 2020

Mari Mino-Kenudson

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22 February 2020

A John Iafrate

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22 February 2020

Jeffrey A Engelman

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22 February 2020

Patricia Greninger

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22 February 2020

Alice T Shaw

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22 February 2020

Matthew J Niederst

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22 February 2020

Elizabeth L Lockerman

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22 February 2020

Rosa L Frias

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22 February 2020

Justin F Gainor

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22 February 2020

Arnaud Amzallag

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22 February 2020

Dana Lee

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22 February 2020

Anuj Kalsy

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22 February 2020

Maria Gomez-Caraballo

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22 February 2020

Leila Elamine

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22 February 2020

Emily Howe

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22 February 2020

Wooyoung Hur

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22 February 2020

Eugene Lifshits

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22 February 2020

Hayley E Robinson

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22 February 2020

Anthony C Faber

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22 February 2020

Mark M Awad

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22 February 2020

Sridhar Ramaswamy

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22 February 2020

Cyril H Benes

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22 February 2020

language of work or name

English

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publication date

13 November 2014

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22 February 2020

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22 February 2020

volume

346

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22 February 2020

issue

6216

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22 February 2020

page(s)

1480-1486

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The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung Cancer

22 February 2020

cites work

1 reference

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Ceritinib in ALK-rearranged non-small-cell lung cancer

6 July 2018

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The quest to overcome resistance to EGFR-targeted therapies in cancer

6 July 2018

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Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer

6 July 2018

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Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer

6 July 2018

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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,

6 July 2018

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Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer

6 July 2018

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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

6 July 2018

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

6 July 2018

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ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells

6 July 2018

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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

6 July 2018

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Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

6 July 2018

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Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

6 July 2018

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6 July 2018

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Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors

6 July 2018

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6 July 2018

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Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency

6 July 2018

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

6 July 2018

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Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

6 July 2018

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6 July 2018

1 reference

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6 July 2018

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Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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affy--analysis of Affymetrix GeneChip data at the probe level

6 July 2018

1 reference

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Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src

6 July 2018

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6 July 2018

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27 October 2018

Identifiers

DOI

10.1126/SCIENCE.1254721

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394791%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25394791%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

25394791

1 reference

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