Toxic proteins released from mitochondria in cell death (Q35743127)

10 August 2017

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title

Toxic proteins released from mitochondria in cell death (English)

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10 August 2017

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Nele Festjens

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Peter Vandenabeele

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Xavier Saelens

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10 August 2017

Geert van Loo

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10 August 2017

author name string

Lieselotte Vande Walle

series ordinal

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10 August 2017

Maria van Gurp

series ordinal

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

2861-2874

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Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Direct evidence for secondary loss of mitochondria in Entamoeba histolytica

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Three-dimensional imaging of biological complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Cellular lipid binding proteins as facilitators and regulators of lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

PDZ domains: structural modules for protein complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Mitochondrial Genome Evolution and the Origin of Eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

NADH oxidase activity of mitochondrial apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Dimer formation drives the activation of the cell death protease caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Caspase-9 can be activated without proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

DNA binding is required for the apoptogenic action of apoptosis inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Mitochondrial control of nuclear apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

Effect of x-irradiation upon the enzyme systems of the mouse spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Structural basis of caspase-7 inhibition by XIAP

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Apoptotic and necrotic cell death induced by death domain receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

More than one way to die: apoptosis, necrosis and reactive oxygen damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Origin of eukaryotic programmed cell death: a consequence of aerobic metabolism?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Structural Basis of Caspase Inhibition by XIAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Role of Smac in human leukaemic cell apoptosis and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

The harlequin mouse mutation downregulates apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Acyl-CoA-binding protein is a potent m-calpain activator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Mitochondrial endonuclease G is important for apoptosis in C. elegans.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

The Escherichia coli heat shock protease HtrA participates in defense against oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Mitochondrial release of caspase-2 and -9 during the apoptotic process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Caspases are not localized in mitochondria during life or death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Injected cytochrome c induces apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207523

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207523

1 reference

10 August 2017

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