Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. (Q35208164)

7 August 2017

title

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. (English)

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7 August 2017

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J J Jacobs

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7 August 2017

B Scheijen

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7 August 2017

J W Voncken

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7 August 2017

K Kieboom

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7 August 2017

A Berns

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7 August 2017

M van Lohuizen

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7 August 2017

publication date

1 October 1999

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

2678-2690

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Nucleolar Arf sequesters Mdm2 and activates p53

7 August 2017

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

28 July 2018

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

28 July 2018

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28 July 2018

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Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

28 July 2018

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

28 July 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

28 July 2018

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Proteins of the Myc network: essential regulators of cell growth and differentiation.

28 July 2018

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Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

28 July 2018

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28 July 2018

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bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis

28 July 2018

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28 July 2018

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28 July 2018

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

28 July 2018

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

28 July 2018

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

28 July 2018

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The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.

28 July 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

28 July 2018

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The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

28 July 2018

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

28 July 2018

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Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

28 July 2018

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Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally

28 July 2018

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Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

28 July 2018

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

28 July 2018

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Induction of apoptosis in fibroblasts by c-myc protein

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Cellular memory of transcriptional states by Polycomb-group proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Mechanisms of apoptosis by c-Myc

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

The p16INK4a/CDKN2A tumor suppressor and its relatives.

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Tumor surveillance via the ARF-p53 pathway.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Anchorage-dependent cell cycle progression

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Role of the INK4a locus in tumor suppression and cell mortality.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=317101

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

26 September 2018

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12 December 2020

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

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12 December 2020

Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss

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12 December 2020

Upregulation of endogenous p53 and induction of in vivo apoptosis in B-lineage lymphomas of E(mu)-myc transgenic mice by deregulated c-myc transgene

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12 December 2020

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

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12 December 2020

Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability

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12 December 2020

A matter of life and cell death

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12 December 2020

Identifiers

DOI

10.1101/GAD.13.20.2678

1 reference

7 August 2017

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7 August 2017

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