Involvement of the INK4a/Arf gene locus in senescence (Q35185629)

7 August 2017

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title

Involvement of the INK4a/Arf gene locus in senescence (English)

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7 August 2017

John M Sedivy

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7 August 2017

Carol J Collins

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7 August 2017

language of work or name

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1 June 2003

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

145-150

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

7 August 2017

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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence

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One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus

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Phosphorylation of p16INK4A correlates with Cdk4 association

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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Telomeres shorten during ageing of human fibroblasts

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Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

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Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

21 January 2018

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Cell-cycle regulators and cancer

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.

21 January 2018

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Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

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Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line

21 January 2018

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Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

21 January 2018

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

21 January 2018

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Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors

21 January 2018

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

21 January 2018

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A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

21 January 2018

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The p16INK4a/CDKN2A tumor suppressor and its relatives.

21 January 2018

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Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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Cellular senescence: mitotic clock or culture shock?

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The RB and p53 pathways in cancer

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21 January 2018

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Different telomere damage signaling pathways in human and mouse cells

21 January 2018

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Cell-cycle inhibitors: three families united by a common cause

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

21 January 2018

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Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

21 January 2018

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Historical claims and current interpretations of replicative aging

21 January 2018

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Oxidative stress shortens telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

A matter of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

Mitochondrial dysfunction leads to telomere attrition and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1474-9728.2003.00048.X

The serial cultivation of human diploid cell strains

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/0014-4827(61)90192-6

Identifiers

DOI

10.1046/J.1474-9728.2003.00048.X

1 reference

7 August 2017

1 reference