CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis (Q46492957)

22 December 2017

title

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis (English)

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22 December 2017

author name string

Mirella Lazarov

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22 December 2017

Yoshiaki Kubo

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22 December 2017

Ti Cai

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22 December 2017

Maya Dajee

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22 December 2017

Masahito Tarutani

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22 December 2017

Qun Lin

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22 December 2017

Min Fang

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22 December 2017

Shiying Tao

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22 December 2017

Cheryl L Green

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22 December 2017

Paul A Khavari

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22 December 2017

language of work or name

English

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publication date

23 September 2002

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22 December 2017

published in

Nature Medicine

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22 December 2017

volume

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22 December 2017

issue

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22 December 2017

page(s)

1105-1114

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22 December 2017

Proliferation, cell cycle and apoptosis in cancer

cites work

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Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

21 January 2018

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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Creation of human tumour cells with defined genetic elements

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Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma

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Ras gene mutation and amplification in human nonmelanoma skin cancers

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Photocarcinogenesis in human adult skin grafts

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Understanding Ras: 'it ain't over 'til it's over'.

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

21 January 2018

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Formation of the Ras dimer is essential for Raf-1 activation

21 January 2018

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Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells

21 January 2018

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In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa

21 January 2018

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Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis

21 January 2018

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Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

21 January 2018

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Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

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C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest

21 January 2018

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

21 January 2018

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Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis

21 January 2018

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Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).

21 January 2018

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Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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A genome-wide survey of RAS transformation targets

21 January 2018

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MDM2 and CDK4 gene amplification in Ewing's sarcoma

21 January 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

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Ras activation in human breast cancer

21 January 2018

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cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain

21 January 2018

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

21 January 2018

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

21 January 2018

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Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype

21 January 2018

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Biological assays for Ras transformation

21 January 2018

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Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1

21 January 2018

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

21 January 2018

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Relationship between Ras pathways and cell cycle control.

21 January 2018

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Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

21 January 2018

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Alterations of p53, pRb, cyclin D(1) and cdk4 in human oral and pharyngeal squamous cell carcinomas

21 January 2018

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Inverse expression of Cdk4 and p16 in epithelial ovarian tumors

21 January 2018

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Nonmelanoma skin cancer in the United States: incidence.

21 January 2018

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Vascular endothelial growth factor expression in head and neck squamous cell carcinoma

21 January 2018

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An immunohistochemical study of E-cadherin expression in human squamous cell carcinoma of the skin: relationship between decreased expression of E-cadherin in the primary lesion and regional lymph node metastasis

21 January 2018

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Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NM779

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22 December 2017

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22 December 2017