Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (Q35101307)

6 August 2017

title

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis (English)

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6 August 2017

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Roland Nilsson

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Jeong Hyun Lee

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Vamsi K Mootha

1 reference

6 August 2017

Fabiana Perocchi

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6 August 2017

Vishal M Gohil

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6 August 2017

Sunil A Sheth

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6 August 2017

Andrew P Wojtovich

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6 August 2017

William Chen

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6 August 2017

Clary B Clish

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6 August 2017

Cenk Ayata

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6 August 2017

Paul S Brookes

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6 August 2017

language of work or name

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14 February 2010

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

249-255

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

6 August 2017

cites work

1 reference

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A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

9 July 2018

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Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use.

9 July 2018

1 reference

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Cardioprotection by metabolic shut-down and gradual wake-up

9 July 2018

1 reference

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The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels

9 July 2018

1 reference

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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

9 July 2018

1 reference

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

9 July 2018

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The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning

9 July 2018

1 reference

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Large-scale chemical dissection of mitochondrial function

9 July 2018

1 reference

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

9 July 2018

1 reference

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Therapeutic hypothermia for global and focal ischemic brain injury--a cool way to improve neurologic outcomes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Harnessing the hypoxia-inducible factor in cancer and ischemic disease

9 July 2018

1 reference

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

9 July 2018

1 reference

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Hypoxia tolerance in mammals and birds: from the wilderness to the clinic

9 July 2018

1 reference

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Current perspectives on the mechanism of action of artemisinins

9 July 2018

1 reference

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Cerebral preconditioning and ischaemic tolerance

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

9 July 2018

1 reference

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On the Origin of Cancer Cells

9 July 2018

1 reference

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Behavioral characterization of mice lacking histamine H(3) receptors.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

The developmental toxicity of the H1 histamine antagonists

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Nonviability of cells with oxidative defects in galactose medium: a screening test for affected patient fibroblasts

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Can radiation-induced apoptosis be modulated by inhibitors of energy metabolism?

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Blockade of electron transport during ischemia protects cardiac mitochondria

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning".

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Mitochondrial generation of reactive oxygen species after brain ischemia in the rat.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135002

Experimental teratology with Meclozine

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20160716

12 December 2020

inferred from PubMed ID database lookup

Maximum oxidative phosphorylation capacity of the mammalian heart

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20160716

12 December 2020

inferred from PubMed ID database lookup

BAD: undertaker by night, candyman by day.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNBT.1606

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NBT.1606

1 reference

Dimensions Publication ID

6 August 2017

1021138603

0 references

Fatcat ID

release_cy2amzohrve5tnti7moknd7yji

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cy2amzohrve5tnti7moknd7yji

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3135002

1 reference

6 August 2017

1 reference