Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (Q42523283)

1 November 2017

title

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (English)

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1 November 2017

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Peggy Lafuste

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Alexandra Grosfeld

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Antonio Diez-Juan

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Nam Ho Jeoung

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Patrick Maxwell

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Johan Nuyts

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Erich Gnaiger

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Diether Lambrechts

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1 November 2017

Peter Carmeliet

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Lieve Moons

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1 November 2017

Paul Van Veldhoven

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Marc Tjwa

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1 November 2017

Julian Aragones Lopez

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Julián Aragonés

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Benedicte Jordan

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1 November 2017

Bernard Gallez

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Tom Dresselaers

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Katrien De Bock

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Serena Zacchigna

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Florea Lupu

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Martin Schneider

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Katie Van Geyte

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Peter Fraisl

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Ruud Dirkx

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Hélène Lemieux

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Tammie Bishop

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Sarah K Harten

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Pieter Van Noten

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Carsten Willam

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Rachel Navet

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Thierry Vandendriessche

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Christophe Deroose

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Bhathiya Wijeyekoon

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Robert Silasi-Mansat

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Mieke Dewerchin

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Chris Pugh

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Phil Salmon

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Luc Mortelmans

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Frans Gorus

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Johan Buyse

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Francis Sluse

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Robert A Harris

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Peter Hespel

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Paul Van Hecke

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Frans Schuit

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Myriam Baes

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1 November 2017

language of work or name

English

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publication date

6 January 2008

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1 November 2017

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1 November 2017

page(s)

170-180

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Hypoxia tolerance in mammals and birds: from the wilderness to the clinic

1 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Genes controlling the metabolic switch in hibernating mammals

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Lower extremity muscle activation during horizontal and uphill running

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Regulation of the activity of the pyruvate dehydrogenase complex

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

p66ShcA modulates tissue response to hindlimb ischemia.

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Hypoxia-induced reactive oxygen species formation in skeletal muscle

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Mitochondria, oxidative stress and cell death

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Aconitase: sensitive target and measure of superoxide

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle.

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

A control analysis exploration of the role of ATP utilisation in glycolytic-flux control and glycolytic-metabolite-concentration regulation

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Tolerance to low O2: lessons from invertebrate genetic models

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Targeting HIF-1 for cancer therapy

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Targeting hypoxia tolerance in cancer

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Mitochondria, oxidants, and aging

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Mitochondrial diseases in man and mouse

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Energy and protein metabolism between 3 and 6 weeks of age of male broiler chickens selected for growth rate or for improved food efficiency

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion.

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology.

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage

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https://api.crossref.org/works/10.1038%2FNG.2007.62

7 January 2021

Identifiers

DOI

10.1038/NG.2007.62

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Dimensions Publication ID

1 November 2017

1025784046

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Fatcat ID

release_hw4bm5kmerbvnh7gcmz3civoxy

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Fatcat

https://api.fatcat.wiki/v0/release/hw4bm5kmerbvnh7gcmz3civoxy

24 November 2022

mapped directly with Wikidata item

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