Current perspectives on the mechanism of action of artemisinins (Q22061943)

7 February 2023

Judith H. Waknine

Judith H

Waknine

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7 February 2023

Miriam Krugliak

Miriam

Krugliak

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7 February 2023

Nicholas H. Hunt

Nicholas H

Hunt

1 reference

7 February 2023

Georges E. Grau

Georges E

Grau

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International Journal for Parasitology

7 February 2023

language of work or name

English

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publication date

December 2006

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published in

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volume

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issue

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page(s)

1427-1441

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cites work

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Artemisinin resistance: how can we find it?

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Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro

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Artemisinin derivatives: toxic for laboratory animals, safe for humans?

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Artemisinin induces omeprazole metabolism in human beings

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Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

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Changes in susceptibility of Plasmodium falciparum to artesunate in vitro in Yunnan Province, China

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Two patients with falciparum malaria and poor in vivo responses to artesunate

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Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

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Artemisinin and its derivatives: an important new class of antimalarial agents

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Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies

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Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates

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Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

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Immunological processes in malaria pathogenesis.

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A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

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Activators and target genes of Rel/NF-kappaB transcription factors

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Testing of chelating agents and vitamins against lead toxicity using mammalian cell cultures

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Reaction of artemisinin with haemoglobin: implications for antimalarial activity

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Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

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Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum

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Seasonal variations of Artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the diploid wild-type

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Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

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The antimalarial drug artemisinin alkylates heme in infected mice

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The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

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Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum

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Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa

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A luminescence method for the quantitative determination of phagocytosis of erythrocytes, of malaria-parasitized erythrocytes and of malarial pigment

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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

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Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials

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Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

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7 January 2021

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

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7 January 2021

Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii

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7 January 2021

Carrier-mediated partitioning of artemisinin into Plasmodium falciparum-infected erythrocytes

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7 January 2021

Neurotoxic mode of action of artemisinin

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7 January 2021

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

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7 January 2021

Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.

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Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum

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7 January 2021

Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?

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7 January 2021

Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

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7 January 2021

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Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo

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7 January 2021

Iron chelators as drugs against malaria pose a potential risk.

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7 January 2021

In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys

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7 January 2021

Yeast model uncovers dual roles of mitochondria in action of artemisinin

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7 January 2021

The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents

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7 January 2021

Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line

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7 January 2021

The safety of antimalarial drugs in pregnancy

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7 January 2021

New trends in extraction, identification and quantification of artemisinin and its derivatives

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Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.

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7 January 2021

Qinghaosu-induced changes in the morphology of Plasmodium inui.

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7 January 2021

Light Microscopic Changes in Plasmodium falciparum from Gabonese Children Treated with Artemether

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7 January 2021

Neuropathologic toxicity of artemisinin derivatives in a mouse model.

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7 January 2021

Association of failures of seven-day courses of artesunate in a non-immune population in Bangui, Central African Republic with decreased sensitivity of Plasmodium falciparum.

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7 January 2021

A case-control auditory evaluation of patients treated with artemether-lumefantrine.

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