Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. (Q34624551)

3 August 2017

title

Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. (English)

1 reference

3 August 2017

1 reference

Bart De Strooper

1 reference

3 August 2017

Lujia Zhou

1 reference

3 August 2017

Lucia Chávez-Gutiérrez

1 reference

3 August 2017

Katrijn Bockstael

1 reference

3 August 2017

Ragna Sannerud

1 reference

3 August 2017

Wim Annaert

1 reference

3 August 2017

Patrick C May

1 reference

3 August 2017

Eric Karran

1 reference

3 August 2017

language of work or name

English

0 references

publication date

5 January 2011

1 reference

Journal of Biological Chemistry

3 August 2017

published in

1 reference

3 August 2017

volume

286

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3 August 2017

1 reference

3 August 2017

page(s)

8677-8687

1 reference

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

3 August 2017

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7 July 2018

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7 July 2018

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Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.

7 July 2018

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Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

7 July 2018

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7 July 2018

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Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

7 July 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

7 July 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

7 July 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

7 July 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

7 July 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

7 July 2018

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7 July 2018

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

7 July 2018

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7 July 2018

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Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

7 July 2018

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7 July 2018

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7 July 2018

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A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.

7 July 2018

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Fragment-Based Drug Discovery

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

21 January 2018

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Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

21 January 2018

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Positive reactions on Western blots do not necessarily indicate the epitopes on antigens are continuous

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

26 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21209097

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.194860

1 reference

release_zhatdy7ezbd2bnro237efxxesi

3 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zhatdy7ezbd2bnro237efxxesi

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3048749

1 reference

3 August 2017

1 reference