c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation (Q34452497)

2 August 2017

title

c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation (English)

1 reference

2 August 2017

1 reference

David L Waning

1 reference

2 August 2017

Jason A Lehman

series ordinal

1 reference

2 August 2017

Christopher N Batuello

series ordinal

1 reference

2 August 2017

Lindsey D Mayo

series ordinal

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2 August 2017

language of work or name

English

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publication date

16 November 2010

1 reference

Journal of Biological Chemistry

2 August 2017

published in

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2 August 2017

volume

286

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2 August 2017

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2 August 2017

page(s)

216-222

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Controlling the Mdm2-Mdmx-p53 Circuit

2 August 2017

cites work

1 reference

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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

6 July 2018

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Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response

6 July 2018

1 reference

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Tumour suppression by p53: a role for the DNA damage response?

6 July 2018

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c-Abl phosphorylates Hdmx and regulates its interaction with p53.

6 July 2018

1 reference

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Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

6 July 2018

1 reference

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

6 July 2018

1 reference

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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

6 July 2018

1 reference

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Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

6 July 2018

1 reference

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C-Abl as a modulator of p53.

6 July 2018

1 reference

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Control of biochemical reactions through supramolecular RING domain self-assembly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

MdmX protects p53 from Mdm2-mediated degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Interaction between ATM protein and c-Abl in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012977

c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.183012

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.183012

P53-independent down-regulation of Mdm2 in human cancer cells treated with adriamycin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21081495

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.183012

1 reference

2 August 2017

1 reference

2 August 2017

1 reference