The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop (Q24297633)

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8 January 2020

title

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop (English)

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8 January 2020

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

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8 January 2020

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Xiongbin Lu

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8 January 2020

Ou Ma

series ordinal

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8 January 2020

Stephen N Jones

series ordinal

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8 January 2020

Lawrence A Donehower

series ordinal

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language of work or name

English

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publication date

1 October 2007

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volume

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issue

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8 January 2020

page(s)

342-354

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Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

8 January 2020

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Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

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Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

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The p53-Mdm2 module and the ubiquitin system.

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Cyclin G recruits PP2A to dephosphorylate Mdm2

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A dynamic role of HAUSP in the p53-Mdm2 pathway

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Surfing the p53 network

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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The complexity of p53 stabilization and activation

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7 January 2021

The p53 pathway: positive and negative feedback loops

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The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

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The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

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The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

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7 January 2021

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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7 January 2021

Cell cycle regulation and p53 activation by protein phosphatase 2C alpha

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7 January 2021

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

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Consolidated OpenCitations Corpus – April 2017

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8 January 2020

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Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17936559%20AND%20SRC:MED&resulttype=core&format=json