Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits (Q34376044)

1 August 2017

title

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits (English)

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1 August 2017

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Mauro Fà

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Luciano D'Adamio

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Ottavio Arancio

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Robert Tamayev

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1 August 2017

Shuji Matsuda

series ordinal

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1 August 2017

language of work or name

English

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publication date

22 November 2010

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

107

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1 August 2017

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1 August 2017

page(s)

20822-20827

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2996452/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

1 reference

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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

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Generation and initial characterization of FDD knock in mice

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Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

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BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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BRI2 (ITM2b) inhibits Abeta deposition in vivo

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6 July 2018

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BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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Axonal transport of British and Danish amyloid peptides via secretory vesicles

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A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

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6 July 2018

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6 July 2018

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6 July 2018

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Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

6 July 2018

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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

6 July 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1011689107

Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

21 January 2018

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Crossref

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Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

21 January 2018

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Exposing rats to a predator impairs spatial working memory in the radial arm water maze.

21 January 2018

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27 October 2018

Identifiers

DOI

10.1073/PNAS.1011689107

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1 August 2017

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1 August 2017

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