STING and the innate immune response to nucleic acids in the cytosol (Q34317532)

1 August 2017

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title

STING and the innate immune response to nucleic acids in the cytosol (English)

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1 August 2017

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Dara L Burdette

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1 August 2017

Russell E Vance

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 January 2013

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

19-26

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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

1 August 2017

cites work

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12 December 2020

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

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12 December 2020

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.

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12 December 2020

Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection

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12 December 2020

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

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12 December 2020

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

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12 December 2020

Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates

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12 December 2020

DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

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12 December 2020

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

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12 December 2020

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

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12 December 2020

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.

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12 December 2020

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

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12 December 2020

Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells

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12 December 2020

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

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12 December 2020

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

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12 December 2020

Roles of cyclic diguanylate in the regulation of bacterial pathogenesis

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12 December 2020

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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12 December 2020

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

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12 December 2020

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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12 December 2020

Structure and evolution of transcriptional regulatory networks

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12 December 2020

Activation of STAT6 by STING is critical for antiviral innate immunity

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12 December 2020

Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages

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12 December 2020

Cyclic di-GMP sensing via the innate immune signaling protein STING

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12 December 2020

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

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12 December 2020

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

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12 December 2020

Phospholipid synthesis in a membrane fraction associated with mitochondria

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12 December 2020

STING is a direct innate immune sensor of cyclic di-GMP

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12 December 2020

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

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12 December 2020

Nucleic Acid Recognition by the Innate Immune System

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12 December 2020

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

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12 December 2020

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

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12 December 2020

Identification and characterization of a loss-of-function human MPYS variant

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12 December 2020

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

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12 December 2020

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

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12 December 2020

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

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12 December 2020

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

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12 December 2020

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

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12 December 2020

Cellular reactive oxygen species inhibit MPYS induction of IFNβ

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12 December 2020

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

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12 December 2020

Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes

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12 December 2020

Innate immune recognition of, and regulation by, DNA.

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12 December 2020

Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster

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12 December 2020

MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection

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12 December 2020

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

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12 December 2020

Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract

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12 December 2020

Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16

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12 December 2020

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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12 December 2020

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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12 December 2020

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

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12 December 2020

IFI16 is an innate immune sensor for intracellular DNA

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12 December 2020

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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12 December 2020

The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

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12 December 2020

Toll-like receptors in systemic autoimmune disease

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12 December 2020

Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response

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12 December 2020

DNA-dependent activator of interferon-regulatory factors inhibits hepatitis B virus replication

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12 December 2020

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

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12 December 2020

MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

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12 December 2020

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

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12 December 2020

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

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12 December 2020

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

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12 December 2020

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

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12 December 2020

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

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12 December 2020

Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

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12 December 2020

DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells

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12 December 2020

A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells

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12 December 2020

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

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12 December 2020

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

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12 December 2020

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

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12 December 2020

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

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12 December 2020

IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).

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12 December 2020

Bacterial c-di-GMP is an immunostimulatory molecule

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12 December 2020

The structural basis for the sensing and binding of cyclic di-GMP by STING

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12 December 2020

STING mediates neuronal innate immune response following Japanese encephalitis virus infection

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12 December 2020

Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence

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12 December 2020

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

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12 December 2020

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

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12 December 2020

Identifiers

DOI

10.1038/NI.2491

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1 August 2017

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