γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines. (Q34113394)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

γ-Secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Maria B Grant

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Xiaoping Qi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jun Cai

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Qing Ruan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Li Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Sanford L Boye

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Zhijuan Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Renee C Ryals

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Lynn Shaw

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Sergio Caballero

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Michael E Boulton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

1 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

Investigative Ophthalmology Visual Science

19 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

574-585

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

19 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3317409/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

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Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia.

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Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion

5 July 2018

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Influence of Dll4 via HIF-1α-VEGF signaling on the angiogenesis of choroidal neovascularization under hypoxic conditions.

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Angiogenin in age-related macular degeneration

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Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization

5 July 2018

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Regulation of ocular angiogenesis by Notch signaling: implications in neovascular age-related macular degeneration.

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Suppression of Choroidal Neovascularization by N-Acetyl-Cysteine in Mice

5 July 2018

1 reference

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Anti-VEGF Compounds in the Treatment of Neovascular Age Related Macular Degeneration

5 July 2018

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Broad spectrum antiangiogenic treatment for ocular neovascular diseases

5 July 2018

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Notch Signaling in the Vasculature

5 July 2018

1 reference

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Neuroinflammatory processes in Alzheimer's disease

5 July 2018

1 reference

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Presenilin/gamma-Secretase and Inflammation

5 July 2018

1 reference

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PEDF in angiogenic eye diseases

5 July 2018

1 reference

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Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates

5 July 2018

1 reference

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Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

5 July 2018

1 reference

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Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa

5 July 2018

1 reference

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Inflammation and the pathogenesis of age-related macular degeneration.

5 July 2018

1 reference

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Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Vascular endothelial growth factor in eye disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Interactions between APP secretases and inflammatory mediators

5 July 2018

1 reference

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gamma-Secretase: a multifaceted regulator of angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

5 July 2018

1 reference

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Changes in growth factor expression in normal aging of the rat retina

5 July 2018

1 reference

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Retinal and choroidal microangiopathies: therapeutic opportunities.

5 July 2018

1 reference

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Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Restoration of cone vision in a mouse model of achromatopsia

5 July 2018

1 reference

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Vascular endothelial growth factor and its relationship to inflammatory mediators

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

The gamma-secretase complex: membrane-embedded proteolytic ensemble

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Proliferating endothelial cell-specific expression of IGF-I receptor ribozyme inhibits retinal neovascularization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Nicastrin: gatekeeper of the gamma-secretase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Presenilin function and gamma-secretase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Current concepts in the pathogenesis of age-related macular degeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

The role of presenilin cofactors in the gamma-secretase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

The role of oxidative stress in the pathogenesis of age-related macular degeneration.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Production and purification of recombinant adeno-associated virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age‐related macular degeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

PEDF prevents reactive oxygen species generation and retinal endothelial cell damage at high glucose levels

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Age-Related Macular Degeneration

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its beta-catenin-binding region

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Mutant presenilin (A260V) affects Rab8 in PC12D cell

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Abnormal blood vessel development in mice lacking presenilin-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3317409

Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22205609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22205609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1167/IOVS.11-8728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

22205609

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22205609%20AND%20SRC:MED&resulttype=core&format=json