Mutant presenilin (A260V) affects Rab8 in PC12D cell (Q44672721)

5 December 2017

title

Mutant presenilin (A260V) affects Rab8 in PC12D cell (English)

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5 December 2017

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5 December 2017

Mihoko Usami

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5 December 2017

Kikuko Tanaka

series ordinal

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5 December 2017

Hideaki Kume

series ordinal

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5 December 2017

Hiroshi Mori

series ordinal

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5 December 2017

publication date

1 April 2004

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Neurochemistry International

5 December 2017

published in

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5 December 2017

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5 December 2017

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5 December 2017

page(s)

313-320

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

5 December 2017

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

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Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

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7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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7 January 2021

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7 January 2021

Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells

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7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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7 January 2021

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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7 January 2021

Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination

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7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

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7 January 2021

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Human amyloid-beta causes changes in the levels of endothelial protein kinase C and its alpha isoform in vitro

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7 January 2021

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

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7 January 2021

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

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7 January 2021

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Identification and characterization of presenilin I-467, I-463 and I-374.

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals

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7 January 2021

Alzheimer's disease: genes, proteins, and therapy

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

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7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

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7 January 2021

Amyloid beta protein and its 3-kDa fragment are present in the axoplasm fraction of the white matter in human brain

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7 January 2021

Serum is required for release of Alzheimer's amyloid precursor protein in neuroblastoma cells.

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7 January 2021

Presenilins are not required for A beta 42 production in the early secretory pathway

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

10.1016/S0197-0186(03)00176-1

Identifiers

DOI

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5 December 2017

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