PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway (Q33939170)

30 July 2017

title

PEDF regulates vascular permeability by a γ-secretase-mediated pathway (English)

1 reference

30 July 2017

PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway (English)

1 reference

10.1371/JOURNAL.PONE.0021164

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0021164

5 December 2024

Maria B Grant

1 reference

30 July 2017

Jun Cai

1 reference

30 July 2017

Lin Wu

1 reference

30 July 2017

Xiaoping Qi

1 reference

30 July 2017

Sergio Li Calzi

1 reference

30 July 2017

Sergio Caballero

1 reference

30 July 2017

Lynn Shaw

1 reference

30 July 2017

Qing Ruan

1 reference

30 July 2017

Michael E. Boulton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695048

5 December 2024

language of work or name

English

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publication date

17 June 2011

1 reference

full work available at URL

30 July 2017

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021164&type=printable

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695048

https://europepmc.org/articles/PMC3117873

5 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695048

https://europepmc.org/articles/PMC3117873?pdf=render

5 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695048

http://dx.plos.org/10.1371/journal.pone.0021164

5 December 2024

1 reference

10.1371/JOURNAL.PONE.0021164

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0021164

5 December 2024

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

30 July 2017

page(s)

e21164

1 reference

Creative Commons Attribution 4.0 International

30 July 2017

start time

17 June 2011

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization

5 July 2018

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PEDF in angiogenic eye diseases

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Anti-vasopermeability effects of PEDF in retinal-renal disorders

5 July 2018

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5 July 2018

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Antipermeability function of PEDF involves blockade of the MAP kinase/GSK/beta-catenin signaling pathway and uPAR expression.

5 July 2018

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Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

5 July 2018

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Vascular permeability in cardiovascular disease and cancer

5 July 2018

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Regulation of endothelial junctional permeability

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Vascular permeability, vascular hyperpermeability and angiogenesis

5 July 2018

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Blood brain barrier in hypoxic-ischemic conditions

5 July 2018

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gamma-Secretase: a multifaceted regulator of angiogenesis

5 July 2018

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Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

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5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Vascular permeability in ocular disease and the role of tight junctions

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study).

5 July 2018

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Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Decreased pigment epithelium-derived factor expression in human breast cancer progression

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular function

5 July 2018

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Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1

5 July 2018

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5 July 2018

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The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

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5 July 2018

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The role of growth factors in the pathogenesis of diabetic retinopathy

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Vascular endothelial growth factors and angiogenesis in eye disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

The pathogenesis of diabetic retinopathy: old concepts and new questions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Molecular mechanisms of vascular permeability in diabetic retinopathy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Characterization of azurocidin as a permeability factor in the retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

VEGF164Is Proinflammatory in the Diabetic Retina

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

PEDF prevents reactive oxygen species generation and retinal endothelial cell damage at high glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Pigment epithelium-derived factor inhibits advanced glycation end products-induced retinal vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Pathophysiological consequences of VEGF-induced vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0021164

Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

VEGF-initiated blood-retinal barrier breakdown in early diabetes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3117873

Effect of 'hypoxia' on the proliferation of microvascular cells in vitro

29 October 2018

1 reference

12 December 2020

Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

1 reference

12 December 2020

Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles

1 reference

12 December 2020

Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0021164

Identifiers

DOI

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference