Kynurenine 3-monooxygenase (Q22677353)

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mammalian protein found in Homo sapiens

kynurenine 3-monooxygenase
kynurenine 3-hydroxylase
KMO

Language	Label	Description	Also known as
English	Kynurenine 3-monooxygenase	mammalian protein found in Homo sapiens	kynurenine 3-monooxygenase kynurenine 3-hydroxylase KMO

Statements

1 reference

13 November 2019

UniProt protein ID

Kynurenine 3-monooxygenase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15229

FAD/NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15229

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FAD-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

NAD(P)H oxidase H2O2-forming activity

determination method or standard

3 references

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Structural basis of kynurenine 3-monooxygenase inhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

monooxygenase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

oxidoreductase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

kynurenine 3-monooxygenase activity

determination method or standard

10 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Structural basis of kynurenine 3-monooxygenase inhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Cloning and functional expression of human kynurenine 3‐monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

flavin adenine dinucleotide binding

determination method or standard

1 reference

24 April 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

kynurenine 3-monooxygenase activity

determination method or standard

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Cloning and functional expression of human kynurenine 3‐monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

NAD(P)H oxidase H2O2-forming activity

determination method or standard

4 references

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

flavin adenine dinucleotide binding

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

mitochondrial outer membrane

determination method or standard

3 references

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

mitochondrial membranes

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

extracellular space

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

mitochondrial outer membrane

determination method or standard

4 references

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

biological process

pyridine nucleotide biosynthetic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

NAD biosynthetic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

response to salt stress

determination method or standard

1 reference

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

secondary metabolite biosynthetic process

determination method or standard

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

tryptophan catabolic process

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

cellular response to interleukin-1

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

L-kynurenine metabolic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

positive regulation of neuron death

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

positive regulation of glutamate secretion, neurotransmission

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

NAD metabolic process

determination method or standard

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

kynurenine metabolic process

determination method or standard

5 references

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

determination method or standard

'de novo' NAD biosynthetic process from tryptophan

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

anthranilate metabolic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

positive regulation of glutamate secretion

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

kynurenic acid biosynthetic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

kynurenine metabolic process

determination method or standard

6 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

determination method or standard

FAD-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15229

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355515

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355515

ENSP00000355516

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355516

ENSP00000355517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355517

ENSP00000355513

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355513

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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