Protein kinases--the major drug targets of the twenty-first century? (Q29615339)

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30 April 2017

Cohen P

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30 April 2017

publication date

April 2002

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Nature Reviews Drug Discovery

30 April 2017

published in

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30 April 2017

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30 April 2017

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30 April 2017

page(s)

309-15

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

30 April 2017

cites work

1 reference

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 May 2017

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 May 2017

1 reference

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 May 2017

1 reference

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

1 May 2017

1 reference

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 May 2017

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 May 2017

1 reference

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

1 May 2017

1 reference

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 May 2017

1 reference

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 May 2017

1 reference

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 May 2017

1 reference

Protein kinase activity associated with the avian sarcoma virus src gene product

1 May 2017

1 reference

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

21 January 2018

1 reference

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

1 reference

Potent selective inhibitors of protein kinase C

21 January 2018

1 reference

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

21 January 2018

1 reference

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

21 January 2018

1 reference

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

21 January 2018

1 reference

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

Rapamycin's resurrection: a new way to target the cancer cell cycle

21 January 2018

1 reference

Statistical significance of probabilistic sequence alignment and related local hidden Markov models.

21 January 2018

1 reference

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

1 reference

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

1 reference

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

1 reference

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

21 January 2018

1 reference

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

21 January 2018

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

21 January 2018

1 reference

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

21 January 2018

1 reference

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

21 January 2018

1 reference

Epidermal growth factor receptor tyrosine kinase. Investigation of catalytic mechanism, structure-based searching and discovery of a potent inhibitor

21 January 2018

1 reference

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

21 January 2018

1 reference

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

21 January 2018

1 reference

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

21 January 2018

1 reference

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

21 January 2018

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

21 January 2018

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

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Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

21 January 2018

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

21 January 2018

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The origins of protein phosphorylation

21 January 2018

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Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial

31 March 2020

1 reference

Salt form selection and characterization of LY333531 mesylate monohydrate

31 March 2020

1 reference

Discovery of a Ca2+- and calmodulin-dependent protein phosphatase: probable identity with calcineurin (CaM-BP80)

31 March 2020

1 reference

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

31 March 2020

1 reference

p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

31 March 2020

1 reference

Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002

31 March 2020

1 reference

From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents

31 March 2020

1 reference

Small molecule modulators of cyclin-dependent kinases for cancer therapy

31 March 2020

1 reference

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31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1011169875

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12120282

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017