Protein kinases--the major drug targets of the twenty-first century? (Q29615339)

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scientific article (publication date: April 2002)

Language	Label	Description	Also known as
English	Protein kinases--the major drug targets of the twenty-first century?	scientific article (publication date: April 2002)

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Europe PubMed Central

Protein kinases--the major drug targets of the twenty-first century? (English)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12120282

30 April 2017

author name string

Cohen P

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30 April 2017

language of work or name

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30 April 2017

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April 2002

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30 April 2017

Nature Reviews Drug Discovery

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30 April 2017

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30 April 2017

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30 April 2017

309-15

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30 April 2017

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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Potent selective inhibitors of protein kinase C

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The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

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Statistical significance of probabilistic sequence alignment and related local hidden Markov models.

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

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30 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12120282

30 April 2017

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