Caspase-activation pathways in apoptosis and immunity (Q28678653)

6 February 2017

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Europe PubMed Central

title

Caspase-activation pathways in apoptosis and immunity (English)

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6 February 2017

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Helen Conroy

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Seamus J. Martin

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6 February 2017

Emma M. Creagh

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6 February 2017

Helen Conroy

series ordinal

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6 February 2017

language of work or name

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1 June 2003

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6 February 2017

June 2003

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published in

Immunological Reviews

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6 February 2017

volume

193

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6 February 2017

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10–21

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

6 February 2017

10-21

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cites work

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7 January 2021

Caspases: enemies within

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Caspases: the executioners of apoptosis

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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Serial killers: ordering caspase activation events in apoptosis

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Apoptotic pathways: the roads to ruin

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Mechanisms mediating caspase activation in cell death

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Protease activation during apoptosis: death by a thousand cuts?

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

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Reprieval from execution: the molecular basis of caspase inhibition

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Caspase knockouts: matters of life and death.

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

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Mitochondria and apoptosis

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The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

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7 January 2021

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

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7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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7 January 2021

Death receptors: signaling and modulation

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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7 January 2021

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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7 January 2021

Caspase-10 is an initiator caspase in death receptor signaling

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7 January 2021

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

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7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

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7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

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7 January 2021

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

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7 January 2021

Cleavage of caspase family members by granzyme B: a comparative study in vitro

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7 January 2021

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

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7 January 2021

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

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7 January 2021

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

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7 January 2021

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

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7 January 2021

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

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7 January 2021

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

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7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

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7 January 2021

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

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7 January 2021

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

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7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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7 January 2021

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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A novel Apaf-1-independent putative caspase-2 activation complex

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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RAIDD is a new 'death' adaptor molecule

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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Bcl-2 regulates the levels of the cysteine proteases ICH and CPP32/Yama in human neuronal precursor cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

7 January 2021

Need for caspase-2 in apoptosis of growth-factor-deprived PC12 cells

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

7 January 2021

Defects in regulation of apoptosis in caspase-2-deficient mice

1 reference

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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

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Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

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Human caspase 12 has acquired deleterious mutations

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

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Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1 reference

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo

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Use of monoclonal antibodies to study interleukin-1 beta-converting enzyme expression: only precursor forms are detected in interleukin-1 beta-secreting cells

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The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

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A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells

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Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases

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Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases

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Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme

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Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme

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Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma

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1 reference

7 January 2021

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

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RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

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PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00048.X

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Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins

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Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing

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7 January 2021

10.1034/J.1600-065X.2003.00048.X

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1 reference