The mitochondrial apoptosome: a killer unleashed by the cytochrome seas (Q34282482)

1 August 2017

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title

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas (English)

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Gene Ontology release 2020-05-02

1 August 2017

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Adrain C

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1 August 2017

Martin SJ

series ordinal

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1 August 2017

publication date

1 June 2001

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Trends in Biochemical Sciences

1 August 2017

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inferred from page(s)

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

390-397

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Programmed cell death in animal development

1 August 2017

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CD95's deadly mission in the immune system

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

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7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

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Caspase-9 and APAF-1 form an active holoenzyme

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Mitochondrial control of apoptosis

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Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

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BCL-2 family members and the mitochondria in apoptosis

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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7 January 2021

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

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7 January 2021

Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

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7 January 2021

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

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7 January 2021

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

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7 January 2021

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

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7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

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7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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7 January 2021

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7 January 2021

Caspase-9 can be activated without proteolytic processing

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7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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7 January 2021

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7 January 2021

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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7 January 2021

Negative regulation of the Apaf-1 apoptosome by Hsp70

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7 January 2021

X-linked IAP is a direct inhibitor of cell-death proteases

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7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

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7 January 2021

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

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7 January 2021

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7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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7 January 2021

10.1016/S0968-0004(01)01844-8

Identifiers

DOI

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1 August 2017

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