Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer (Q28586302)

31 January 2017

title

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer (English)

1 reference

Partner and localizer of BRCA2

31 January 2017

main subject

1 reference

GOA release 2020-03-11

Christiaan Klijn

Christiaan

Klijn

1 reference

21 October 2023

Jos

Jonkers

Jos Jonkers

1 reference

31 January 2017

author name string

Christian Bowman-Colin

Christian

Bowman-Colin

1 reference

31 January 2017

Bing Xia

Bing

Xia

1 reference

31 January 2017

Samuel Bunting

Samuel

Bunting

1 reference

31 January 2017

Rinske Drost

Rinske

Drost

1 reference

31 January 2017

Peter Bouwman

Peter

Bouwman

1 reference

31 January 2017

Laura Fineman

Laura

Fineman

1 reference

31 January 2017

Xixi Chen

Xixi

Chen

1 reference

31 January 2017

Aedin C. Culhane

Aedin C

Culhane

1 reference

31 January 2017

Hong Cai

Hong

Cai

1 reference

31 January 2017

Scott J. Rodig

Scott J

Rodig

1 reference

31 January 2017

Roderick T. Bronson

Roderick T

Bronson

1 reference

31 January 2017

Andre Nussenzweig

Andre

Nussenzweig

1 reference

31 January 2017

Chryssa Kanellopoulou

Chryssa

Kanellopoulou

1 reference

31 January 2017

David M. Livingston

David M

Livingston

1 reference

31 January 2017

language of work or name

English

0 references

publication date

21 May 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 January 2017

published in

1 reference

31 January 2017

volume

110

1 reference

31 January 2017

1 reference

31 January 2017

page(s)

8632–8637

1 reference

ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

31 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Penetrance analysis of the PALB2 c.1592delT founder mutation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Analysis of PALB2/FANCN-associated breast cancer families

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Molecular views of recombination proteins and their control

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Sonic hedgehog regulates growth and morphogenesis of the tooth

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Brca2 is required for embryonic cellular proliferation in the mouse

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Evolutionary pathways in BRCA1-associated breast tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

29 September 2017

Mouse Models of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

MRG15 is a novel PALB2-interacting factor involved in homologous recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

X chromosome inactivation in the absence of Dicer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Chromosome aberrations in solid tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Tumorigenesis in mice carrying a truncating Brca1 mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

Embryonic stem cells alone are able to support fetal development in the mouse.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3666744

A recurrent mutation in PALB2 in Finnish cancer families.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1305362110

Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1305362110

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1305362110

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1305362110

Analysis of FANCB and FANCN/PALB2 Fanconi Anemia genes in BRCA1/2-negative Spanish breast cancer families

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1305362110

21 January 2018

Identifiers

DOI

10.1073/PNAS.1305362110

1 reference

ADS bibcode

2013PNAS..110.8632B

0 references

1 reference

1 reference

1 reference