Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression (Q28512158)

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English	Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression	scientific journal article

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scholarly article

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PubMed publication ID

25 January 2017

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression (English)

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PubMed publication ID

25 January 2017

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haploinsufficiency

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Partner and localizer of BRCA2

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GOA release 2020-03-11

Christiaan Klijn

object named as

Christiaan Klijn

3

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object named as

Karoly Szuhai

7

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8

object named as

Jos Jonkers

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PubMed publication ID

25 January 2017

author name string

Peter Bouwman

1

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PubMed publication ID

25 January 2017

Rinske Drost

2

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PubMed publication ID

25 January 2017

Mark Pieterse

4

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PubMed publication ID

25 January 2017

Hanneke van der Gulden

5

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PubMed publication ID

25 January 2017

Ji-Ying Song

6

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PubMed publication ID

25 January 2017

publication date

1 May 2011

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PubMed publication ID

25 January 2017

Journal of Pathology

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PubMed publication ID

25 January 2017

224

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PubMed publication ID

25 January 2017

1

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PubMed publication ID

25 January 2017

10–21

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PubMed publication ID

25 January 2017

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

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https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

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https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

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https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Susceptibility pathways in Fanconi's anemia and breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Biallelic inactivation of BRCA2 in Fanconi anemia

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Ten genes for inherited breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

A recurrent mutation in PALB2 in Finnish cancer families.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Analysis of PALB2/FANCN-associated breast cancer families

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

BRCA2-null embryonic survival is prolonged on the BALB/c genetic background.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Brca2 is required for embryonic cellular proliferation in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

COBRA: combined binary ratio labeling of nucleic-acid probes for multi-color fluorescence in situ hybridization karyotyping

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

A faster circular binary segmentation algorithm for the analysis of array CGH data

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

MRG15 is a novel PALB2-interacting factor involved in homologous recombination

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

A new model of patient tumor-derived breast cancer xenografts for preclinical assays

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Significance analysis of microarrays applied to the ionizing radiation response

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

New strategy for multi-colour fluorescence in situ hybridisation: COBRA: COmbined Binary RAtio labelling

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2861

21 January 2018

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