A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. (Q46229708)

20 December 2017

title

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. (English)

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20 December 2017

author

Adrian Smith

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ORCID Public Data File 2021

author name string

C Spruck

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20 December 2017

H Strohmaier

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20 December 2017

M Watson

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20 December 2017

A P Smith

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20 December 2017

A Ryan

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20 December 2017

T W Krek

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20 December 2017

S I Reed

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20 December 2017

publication date

1 March 2001

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20 December 2017

published in

Molecular Cell

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20 December 2017

volume

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20 December 2017

issue

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20 December 2017

page(s)

639-650

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20 December 2017

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

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The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex

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Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

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7 January 2021

Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

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7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae

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7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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7 January 2021

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7 January 2021

A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly

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7 January 2021

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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7 January 2021

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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7 January 2021

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Identifiers

DOI

1 reference

20 December 2017

1 reference

20 December 2017