Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover (Q34277719)

1 August 2017

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title

Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover (English)

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1 August 2017

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Steven I Reed

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1 August 2017

publication date

1 November 2003

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Nature Reviews Molecular Cell Biology

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

855-864

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Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1 August 2017

cites work

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Ubiquitin: Roles in protein modification and breakdown

31 March 2020

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Control of enzyme levels in animal tissues

31 March 2020

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Synthesis of labile, serum-dependent protein in early G 1 controls animal cell growth

31 March 2020

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Cyclin is degraded by the ubiquitin pathway

31 March 2020

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An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells

31 March 2020

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P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae

31 March 2020

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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

31 March 2020

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Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

31 March 2020

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The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1)

31 March 2020

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

31 March 2020

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Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

31 March 2020

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Cdk inhibitors in development and cancer

31 March 2020

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

31 March 2020

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

31 March 2020

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Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

31 March 2020

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

31 March 2020

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A detailed analysis of cyclin A accumulation at the G(1)/S border in normal and transformed cells

31 March 2020

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Inhibition of cyclin-dependent kinases by p21

31 March 2020

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Inhibitors of mammalian G1 cyclin-dependent kinases

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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p107 and p130: versatile proteins with interesting pockets

31 March 2020

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The retinoblastoma family: twins or distant cousins?

31 March 2020

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Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

31 March 2020

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31 March 2020

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Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

31 March 2020

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

31 March 2020

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Segregating sister genomes: the molecular biology of chromosome separation

31 March 2020

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An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

31 March 2020

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A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

31 March 2020

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Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

31 March 2020

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Securin is required for chromosomal stability in human cells

31 March 2020

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Cyclin destruction in mitosis: a crucial task of Cdc20.

31 March 2020

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Regulation of the APC and the exit from mitosis

31 March 2020

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Proteolytic ratchets that control progression through mitosis

31 March 2020

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Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

31 March 2020

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CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

31 March 2020

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Control of DNA replication licensing in a cell cycle

31 March 2020

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Cyclin-dependent kinases and S phase control in mammalian cells

31 March 2020

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Cyclin E in human cancers.

31 March 2020

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Association of human cyclin E with a periodic G1-S phase protein kinase

31 March 2020

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

31 March 2020

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Accumulation of cyclin E is not a prerequisite for passage through the restriction point

31 March 2020

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Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

31 March 2020

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

31 March 2020

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

31 March 2020

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

31 March 2020

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

31 March 2020

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Deregulated cyclin E induces chromosome instability

31 March 2020

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Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

31 March 2020

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Mitotic regulation of the APC activator proteins CDC20 and CDH1

31 March 2020

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The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

31 March 2020

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Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

31 March 2020

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Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

31 March 2020

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The spindle checkpoint: structural insights into dynamic signalling

31 March 2020

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The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis

31 March 2020

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The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

31 March 2020

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Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

31 March 2020

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

31 March 2020

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D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p

31 March 2020

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Three-dimensional structure of the anaphase-promoting complex

31 March 2020

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Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

31 March 2020

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

31 March 2020

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

31 March 2020

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

31 March 2020

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Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes

31 March 2020

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

31 March 2020

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Identification of a family of human F-box proteins

31 March 2020

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A family of mammalian F-box proteins

31 March 2020

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

31 March 2020

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

31 March 2020

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SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities

31 March 2020

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Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

31 March 2020

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Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

31 March 2020

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Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.

31 March 2020

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SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

31 March 2020

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

31 March 2020

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

31 March 2020

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

31 March 2020

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

31 March 2020

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

31 March 2020

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

31 March 2020

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

31 March 2020

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The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

31 March 2020

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Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex

31 March 2020

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Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

31 March 2020

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The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

31 March 2020

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

31 March 2020

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The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

31 March 2020

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Genetic control of the cell division cycle in yeast

31 March 2020

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

31 March 2020

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

31 March 2020

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Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

31 March 2020

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APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

31 March 2020

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The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae

31 March 2020

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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

31 March 2020

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

31 March 2020

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Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation

31 March 2020

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Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

31 March 2020

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31 March 2020

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31 March 2020

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Degradation of human Aurora-A protein kinase is mediated by hCdh1

31 March 2020

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Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex

31 March 2020

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APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle

31 March 2020

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Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

31 March 2020

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Cell cycle-regulated proteolysis of mitotic target proteins

31 March 2020

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

31 March 2020

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Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence

31 March 2020

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Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p

31 March 2020

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The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement

31 March 2020

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Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex

31 March 2020

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Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

31 March 2020

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F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p

31 March 2020

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The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex

31 March 2020

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SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells

31 March 2020

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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

31 March 2020

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Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

31 March 2020

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The role of cyclin E in cell proliferation, development and cancer

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1246

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Dimensions Publication ID

1 August 2017

1004970299

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