Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols

Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

21 January 2018

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The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

21 January 2018

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Bile salts of vertebrates: structural variation and possible evolutionary significance

21 January 2018

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Gonadal ecdysteroidogenesis in arthropoda: occurrence and regulation

21 January 2018

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The nuclear receptor superfamily: a personal retrospect on the first two decades

21 January 2018

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The nuclear receptor superfamily: a rosetta stone for physiology

21 January 2018

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A brief history of adrenal research: steroidogenesis - the soul of the adrenal

21 January 2018

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Minireview: regulation of steroidogenesis by electron transfer

21 January 2018

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Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency

21 January 2018

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Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase

21 January 2018

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Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating.

21 January 2018

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Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders.

21 January 2018

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Enzymes in the conversion of cholesterol into bile acids.

21 January 2018

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Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

21 January 2018

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25-Hydroxyvitamin D 3 1α-Hydroxylase and Vitamin D Synthesis

21 January 2018

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Cytochromes p450: roles in diseases

21 January 2018

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Independent elaboration of steroid hormone signaling pathways in metazoans

21 January 2018

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Evolutionary origin of the mitochondrial cholesterol transport machinery reveals a universal mechanism of steroid hormone biosynthesis in animals

21 January 2018

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Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

21 January 2018

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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

21 January 2018

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Steroid hormone synthesis in mitochondria

21 January 2018

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Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 alpha-hydroxylase/C17-20 lyase in Leydig cells

21 January 2018

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Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease

21 January 2018

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Regulation of steroid production: analysis of Cyp11a1 promoter.

21 January 2018

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Regulation of mitochondrial compartment volumes in rat adrenal cortex by ether stress

21 January 2018

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Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland

21 January 2018

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ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer.

21 January 2018

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Membrane lipids: where they are and how they behave

21 January 2018

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Cellular cholesterol trafficking and compartmentalization

21 January 2018

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Intracellular sterol dynamics

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Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

21 January 2018

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Lipid Trafficking sans Vesicles: Where, Why, How?

21 January 2018

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Lipid droplet formation on opposing sides of the endoplasmic reticulum

21 January 2018

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Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration.

21 January 2018

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Acute effects of ACTH on dissociated adrenocortical cells: Quantitative changes in mitochondria and lipid droplets

21 January 2018

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Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopy

21 January 2018

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Ablation of vimentin results in defective steroidogenesis

21 January 2018

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Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol

21 January 2018

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Lipid lateral diffusion and membrane heterogeneity

21 January 2018

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Chemical activity of cholesterol in membranes

21 January 2018

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Probing red cell membrane cholesterol movement with cyclodextrin

21 January 2018

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Use of cyclodextrins to monitor transbilayer movement and differential lipid affinities of cholesterol

21 January 2018

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Condensed complexes of cholesterol and phospholipids

21 January 2018

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Condensed complexes in vesicles containing cholesterol and phospholipids.

21 January 2018

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How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids

21 January 2018

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Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane

21 January 2018

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Activation of membrane cholesterol by displacement from phospholipids

21 January 2018

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Cholesterol displacement from membrane phospholipids by hexadecanol

21 January 2018

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A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers

21 January 2018

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Assess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayers

21 January 2018

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21 January 2018

Lipids of mitochondria

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Use of cytochrome P-450scc to measure cholesterol-lipid interactions

21 January 2018

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Mechanisms and consequences of cellular cholesterol exchange and transfer.

21 January 2018

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Non-vesicular lipid transport by lipid-transfer proteins and beyond

21 January 2018

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The mammalian START domain protein family in lipid transport in health and disease

21 January 2018

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The diverse functions of oxysterol-binding proteins

21 January 2018

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21 January 2018

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The pathophysiology and genetics of congenital lipoid adrenal hyperplasia.

21 January 2018

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Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis

21 January 2018

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Clinical, genetic, and functional characterization of four patients carrying partial loss-of-function mutations in the steroidogenic acute regulatory protein (StAR).

21 January 2018

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Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia

21 January 2018

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The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis.

21 January 2018

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Rapid regulation of steroidogenesis by mitochondrial protein import

21 January 2018

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Complex role of the mitochondrial targeting signal in the function of steroidogenic acute regulatory protein revealed by bacterial artificial chromosome transgenesis in vivo.

21 January 2018

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Structure and lipid transport mechanism of a StAR-related domain

21 January 2018

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Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

21 January 2018

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Comparative structural analysis of lipid binding START domains

21 January 2018

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Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol.

21 January 2018

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Validation of the mechanism of cholesterol binding by StAR using short molecular dynamics simulations

21 January 2018

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Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein

21 January 2018

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Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics

21 January 2018

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Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

21 January 2018

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Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells

21 January 2018

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Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR.

21 January 2018

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Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.

21 January 2018

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The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

21 January 2018

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A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR.

21 January 2018

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pH-dependent Interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes

21 January 2018

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Niemann-Pick disease type C.

21 January 2018

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Identification of 58 novel mutations in Niemann-Pick disease type C: correlation with biochemical phenotype and importance of PTC1-like domains in NPC1.

21 January 2018

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Identification of HE1 as the second gene of Niemann-Pick C disease

21 January 2018

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

21 January 2018

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Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease

21 January 2018

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Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

21 January 2018

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

21 January 2018

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Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17

21 January 2018

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The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells

21 January 2018

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Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design.

21 January 2018

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MENTHO, a MLN64 homologue devoid of the START domain

21 January 2018

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N-218 MLN64, a protein with StAR-like steroidogenic activity, is folded and cleaved similarly to StAR.

21 January 2018

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MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis

21 January 2018

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MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site

21 January 2018

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Functional characterization of the MENTAL domain

21 January 2018

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MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria

21 January 2018

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MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

21 January 2018

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Mitochondrial heat shock protein participates in placental steroidogenesis

21 January 2018

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StAR-like activity and molten globule behavior of StARD6, a male germ-line protein.

21 January 2018

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Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

21 January 2018

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Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism

21 January 2018

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MLN64 is involved in actin-mediated dynamics of late endocytic organelles

21 January 2018

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Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1

21 January 2018

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STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER

21 January 2018

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Identification of StARD3 as a Lutein-Binding Protein in the Macula of the Primate Retina

21 January 2018

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Surface plasmon resonance (SPR) studies on the interactions of carotenoids and their binding proteins

21 January 2018

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Isolation, characterization, and cDNA sequence of a carotenoid binding protein from the silk gland of Bombyx mori larvae

21 January 2018

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The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

21 January 2018

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Give lipids a START: the StAR-related lipid transfer (START) domain in mammals.

21 January 2018

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Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts

21 January 2018

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Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules

21 January 2018

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Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress

21 January 2018

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

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Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation

21 January 2018

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STARD4 abundance regulates sterol transport and sensing

21 January 2018

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Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism

21 January 2018

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Interleukin-1beta signals through a c-Jun N-terminal kinase-dependent inducible nitric oxide synthase and nitric oxide production pathway in Sertoli epithelial cells.

21 January 2018

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Localization of StarD5 cholesterol binding protein

21 January 2018

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Human StarD5, a cytosolic StAR-related lipid binding protein

21 January 2018

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ER stress increases StarD5 expression by stabilizing its mRNA and leads to relocalization of its protein from the nucleus to the membranes.

21 January 2018

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21 January 2018

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Thermodynamic and solution state NMR characterization of the binding of secondary and conjugated bile acids to STARD5.

21 January 2018

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Expression of the putative sterol binding protein Stard6 gene is male germ cell specific

21 January 2018

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Acute responses of DNA repair proteins and StarD6 in rat hippocampus after domoic acid-induced excitotoxicity

21 January 2018

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STARD6 is expressed in steroidogenic cells of the ovary and can enhance de novo steroidogenesis

21 January 2018

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Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.

21 January 2018

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A family of 12 human genes containing oxysterol-binding domains

21 January 2018

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Insights into the mechanisms of sterol transport between organelles

21 January 2018

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Functional implications of sterol transport by the oxysterol-binding protein gene family.

21 January 2018

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Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

21 January 2018

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Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

21 January 2018

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A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP

21 January 2018

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Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

21 January 2018

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Diazepam Binding Inhibitor and Its Processing Products Stimulate Mitochondrial Steroid Biosynthesis via an Interaction with Mitochondrial Benzodiazepine Receptors*

21 January 2018

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Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line

21 January 2018

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Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis

21 January 2018

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The translocator protein (TSPO): a novel target for cancer chemotherapy.

21 January 2018

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Translocator protein (18 kDa): a promising therapeutic target and diagnostic tool for cardiovascular diseases

21 January 2018

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21 January 2018

The translocator protein

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Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

21 January 2018

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Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma

21 January 2018

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Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide

21 January 2018

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Structural and functional study of reconstituted peripheral benzodiazepine receptor

21 January 2018

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Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor

21 January 2018

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Novel Androstenetriol Interacts with the Mitochondrial Translocator Protein and Controls Steroidogenesis

21 January 2018

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Structure of the mitochondrial translocator protein in complex with a diagnostic ligand

21 January 2018

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Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor.

21 January 2018

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How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

21 January 2018

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Structure-activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis

21 January 2018

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In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding.

21 January 2018

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In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis

21 January 2018

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The voltage dependent anion channel affects mitochondrial cholesterol distribution and function

21 January 2018

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Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria

21 January 2018

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Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane.

21 January 2018

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Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis

21 January 2018

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Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of steroidogenic acute regulatory protein (StAR)/PBR association in the mitochondrial membrane as determined by bioluminescence resonance energy transfer (BRET)

21 January 2018

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Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones

21 January 2018

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Condensed complexes of cholesterol and phospholipids

21 January 2018

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