Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR. (Q40170960)

18 September 2017

title

Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR. (English)

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18 September 2017

Bo Y Baker

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18 September 2017

Raquel F Epand

series ordinal

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18 September 2017

Richard M Epand

series ordinal

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18 September 2017

Walter L Miller

series ordinal

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18 September 2017

language of work or name

English

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publication date

13 February 2007

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

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18 September 2017

page(s)

10223-10232

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Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StAR.

18 September 2017

cites work

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Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13

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Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action

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Rapid regulation of steroidogenesis by mitochondrial protein import

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pH-dependent Interactions of the carboxyl-terminal helix of steroidogenic acute regulatory protein with synthetic membranes

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The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

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Binding of steroidogenic acute regulatory protein to synthetic membranes suggests an active molten globule

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A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR.

21 January 2018

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Insights into steroidogenic acute regulatory protein (StAR)-dependent cholesterol transfer in mitochondria: evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR.

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Structure and lipid transport mechanism of a StAR-related domain

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Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

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StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import

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Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity

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Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR).

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Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein

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Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics

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Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

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Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells

21 January 2018

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Nonclassic congenital lipoid adrenal hyperplasia: a new disorder of the steroidogenic acute regulatory protein with very late presentation and normal male genitalia

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Construction and function of fusion enzymes of the human cytochrome P450scc system

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N-218 MLN64, a protein with StAR-like steroidogenic activity, is folded and cleaved similarly to StAR.

21 January 2018

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Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein

21 January 2018

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21 January 2018

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Congenital lipoid adrenal hyperplasia: the human gene knockout for the steroidogenic acute regulatory protein

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Structural mechanism for sterol sensing and transport by OSBP-related proteins

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Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides

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The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

21 January 2018

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21 January 2018

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Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M611221200

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18 September 2017

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