Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast (Q27934755)

1 December 2016

title

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast (English)

1 reference

Type I HSP40 co-chaperone YDJ1 YNL064C

PubMed publication ID

1 December 2016

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transmembrane protein

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1 reference

Type I HSP40 co-chaperone HLJ1 YMR161W

GOA release 2020-03-11

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Molecular Biology of the Cell

GOA release 2020-03-11

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Traude Beilharz

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Robert T Youker

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Peter Walsh

series ordinal

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Jeffrey L Brodsky

series ordinal

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language of work or name

English

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publication date

November 2004

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published in

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Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

PubMed publication ID

1 December 2016

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4787-97

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cites work

1 reference

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20 March 2017

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

20 March 2017

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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

20 March 2017

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A SNARE required for retrograde transport to the endoplasmic reticulum

20 March 2017

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Traffic-independent function of the Sar1p/COPII machinery in proteasomal sorting of the cystic fibrosis transmembrane conductance regulator

20 March 2017

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Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae

20 March 2017

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The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70

20 March 2017

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

20 March 2017

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Hsp90: a specialized but essential protein-folding tool

20 March 2017

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Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

20 March 2017

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

20 March 2017

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

20 March 2017

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Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

20 March 2017

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YPD, PombePD and WormPD: model organism volumes of the BioKnowledge library, an integrated resource for protein information

20 March 2017

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Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes

20 March 2017

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The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone

20 March 2017

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The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

20 March 2017

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Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

20 March 2017

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Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

20 March 2017

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SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins

20 March 2017

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Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins

20 March 2017

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Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

20 March 2017

1 reference

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In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

20 March 2017

1 reference

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

20 March 2017

1 reference

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Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo

20 March 2017

1 reference

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Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum

20 March 2017

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YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism

20 March 2017

1 reference

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Regulation of Hsp70 function by a eukaryotic DnaJ homolog

20 March 2017

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

20 March 2017

1 reference

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Hop modulates Hsp70/Hsp90 interactions in protein folding

20 March 2017

1 reference

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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator

20 March 2017

1 reference

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Setting the standards: quality control in the secretory pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Degradation of CFTR by the ubiquitin-proteasome pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

A complete set of SNAREs in yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

29 September 2017

1 reference

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Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

29 September 2017

1 reference

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Signals for COPII-dependent export from the ER: what's the ticket out?

29 September 2017

1 reference

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For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

29 September 2017

1 reference

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The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system

29 September 2017

1 reference

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A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator

29 September 2017

1 reference

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The action of molecular chaperones in the early secretory pathway

29 September 2017

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From the cradle to the grave: molecular chaperones that may choose between folding and degradation

29 September 2017

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Hsp90: chaperoning signal transduction

29 September 2017

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

29 September 2017

1 reference

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Mutation of the ATP-binding pocket of SSA1 indicates that a functional interaction between Ssa1p and Ydj1p is required for post-translational translocation into the yeast endoplasmic reticulum.

29 September 2017

1 reference

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Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40

29 September 2017

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Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system

29 September 2017

1 reference

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Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]

29 September 2017

1 reference

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Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane.

29 September 2017

1 reference

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Hsp90's secrets unfold: new insights from structural and functional studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae

29 September 2017

1 reference

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Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

29 September 2017

1 reference

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Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway

29 September 2017

1 reference

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Defective protein folding as a basis of human disease

29 September 2017

1 reference

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Supervising the fold: functional principles of molecular chaperones

29 September 2017

1 reference

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Isolation of Hsp90 mutants by screening for decreased steroid receptor function

29 September 2017

1 reference

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The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

29 September 2017

1 reference

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Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae

29 September 2017

1 reference

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Hsp90 chaperones protein folding in vitro.

29 September 2017

1 reference

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Sequence motifs shared between chaperone components participating in the assembly of progesterone receptor complexes

29 September 2017

1 reference

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Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights

2 June 2018

1 reference

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Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.

2 June 2018

1 reference

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Functional expression of the cystic fibrosis transmembrane conductance regulator in yeast.

2 June 2018

1 reference

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MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae.

2 June 2018

1 reference

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

2 June 2018

1 reference

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Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

2 June 2018

1 reference

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Expression and degradation of the cystic fibrosis transmembrane conductance regulator in Saccharomyces cerevisiae

27 November 2018

1 reference

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Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Both the N- and C-terminal chaperone sites of Hsp90 participate in protein refolding

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate

27 November 2018

1 reference

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Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway

27 November 2018

1 reference

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The Molecular Chaperone Hsc70 Assists the in VitroFolding of the N-terminal Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

27 November 2018

1 reference

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Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function.

27 November 2018

1 reference

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=524727

Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

27 November 2018

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12 December 2020

CFTR expression and ER-associated degradation in yeast

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12 December 2020

Localization and suppression of a kinetic defect in cystic fibrosis transmembrane conductance regulator folding

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12 December 2020

In vitro evidence that hsp90 contains two independent chaperone sites

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12 December 2020

A Toxic Fusion Protein Accumulating between the Mitochondrial Membranes Inhibits Protein Assemblyin Vivo

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12 December 2020

The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct

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12 December 2020

Control of estrogen receptor ligand binding by Hsp90

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12 December 2020