Hsp90's secrets unfold: new insights from structural and functional studies (Q33659713)

28 July 2017

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title

Hsp90's secrets unfold: new insights from structural and functional studies (English)

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28 July 2017

Caplan AJ

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28 July 2017

publication date

1 July 1999

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28 July 2017

published in

Trends in Cell Biology

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

262-268

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The Hsp70 and Hsp60 chaperone machines

28 July 2017

cites work

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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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Assessment of the ATP binding properties of Hsp90.

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ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

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In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

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Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation

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The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

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Hsp90-mediated folding of the lymphoid cell kinase p56lck

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Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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7 January 2021

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

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Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells

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The Function of Steroid Hormone Receptors Is Inhibited by the hsp90-specific Compound Geldanamycin

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The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70

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7 January 2021

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

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Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

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Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.

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7 January 2021

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

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7 January 2021

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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7 January 2021

Age-dependent association of isolated bovine lens multicatalytic proteinase complex (proteasome) with heat-shock protein 90, an endogenous inhibitor

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

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7 January 2021

In vitro evidence that hsp90 contains two independent chaperone sites

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7 January 2021

Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence

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Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

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Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94.

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

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7 January 2021

The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex.

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7 January 2021

The assembly of progesterone receptor-hsp90 complexes using purified proteins

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7 January 2021

Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

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7 January 2021

Hormone-dependent transactivation by the human androgen receptor is regulated by a dnaJ protein

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7 January 2021

The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast

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7 January 2021

Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways

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7 January 2021

Chaperones get in touch: the Hip-Hop connection

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7 January 2021

Hop modulates Hsp70/Hsp90 interactions in protein folding

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7 January 2021

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

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7 January 2021

A cyclophilin function in Hsp90-dependent signal transduction

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7 January 2021

SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins

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7 January 2021

Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins

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7 January 2021

Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction

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7 January 2021

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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7 January 2021

Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90

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7 January 2021

The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90.

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7 January 2021

A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains

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7 January 2021

CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.

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7 January 2021

Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells

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7 January 2021

In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

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7 January 2021

The peptidyl-prolyl isomerase domain of the CyP-40 cyclophilin homolog Cpr7 is not required to support growth or glucocorticoid receptor activity in Saccharomyces cerevisiae

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7 January 2021

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

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7 January 2021

Cdc37 is a molecular chaperone with specific functions in signal transduction

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7 January 2021

Cdc37: a protein kinase chaperone?

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7 January 2021

Differential in vivo regulation of steroid hormone receptor activation by Cdc37p

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7 January 2021

Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response

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7 January 2021

Hsp90 as a capacitor for morphological evolution

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7 January 2021

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

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7 January 2021

Functional requirement of p23 and Hsp90 in telomerase complexes

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7 January 2021

10.1016/S0962-8924(99)01580-9

Identifiers

DOI

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28 July 2017

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