Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes (Q27316335)

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scientific article (publication date: 2015)

Language	Label	Description	Also known as
English	Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes	scientific article (publication date: 2015)

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scholarly article

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Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes (English)

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Grace Brannigan

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Grace Brannigan

4

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author name string

Thomas Westergard

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Reza Salari

2

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Joseph V Martin

3

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language of work or name

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publication date

2015

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10

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9

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e0139072

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Creative Commons Attribution 4.0 International

30 September 2015

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April 2022 Public Data File from Crossref

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Crystal structure of a human GABAA receptor

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Principles of activation and permeation in an anion-selective Cys-loop receptor

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GABA A receptors: subtypes provide diversity of function and pharmacology

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21 March 2017

General anaesthetic actions on ligand-gated ion channels

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

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21 March 2017

Scalable molecular dynamics with NAMD

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VMD: visual molecular dynamics

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A predicted binding site for cholesterol on the GABAA receptor

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21 March 2017

Neurosteroids: endogenous regulators of the GABA(A) receptor

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21 March 2017

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics

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Some quantitative uses of drug antagonists

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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

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Hyperthyroidism and risk for bipolar disorders: a nationwide population-based study

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Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin

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Ivermectin binding sites in human and invertebrate Cys-loop receptors

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28 September 2017

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.

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28 September 2017

Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor

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28 September 2017

General Anesthetic Actions on GABAA Receptors

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Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain

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The sticky issue of neurosteroids and GABA(A) receptors

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Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop

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Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease

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Why the Schild method is better than Schild realised

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Neurosteroid binding sites on GABA(A) receptors

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Mechanisms of neurosteroid interactions with GABA(A) receptors.

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28 September 2017

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

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GABA-based therapeutic approaches: GABAA receptor subtype functions

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Emerging molecular mechanisms of general anesthetic action.

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28 September 2017

The nature of sites of general anaesthetic action

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Thyroid hormones as neurotransmitters

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Localization of triiodothyronine in nerve ending fractions of rat brain

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Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector

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State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

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Direct channel-gating and modulatory effects of triiodothyronine on recombinant GABA(A) receptors.

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Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique

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Synaptosomal [125I]triiodothyronine after intravenous [125I]thyroxine

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Neurosteroids: endogenous allosteric modulators of GABA(A) receptors.

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The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors

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Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems

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Specific binding of L-triiodothyronine modulates Na(+)-K(+)-ATPase activity in adult rat cerebrocortical synaptosomes

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12 December 2020

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10.1371/JOURNAL.PONE.0139072

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2015PLoSO..1039072W

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