CAR T Cell Therapy: A Game Changer in Cancer Treatment (Q26822769)

T-cell antigen receptor specificity

2 May 2021

1 reference

PubMed publication ID

27298832

chimeric antigen receptor

1 reference

inferred from abstract

Hilde Almåsbak

1 reference

Tanja Aarvak

1 reference

Mohan C. Vemuri

1 reference

language of work or name

1 reference

2016

1 reference

Journal of Immunology Research

19 May 2016

9 references

3 April 2019

25 June 2019

31 July 2019

12 October 2019

18 October 2019

15 December 2019

9 September 2020

8 February 2021

2 May 2021

10 references

3 April 2019

25 June 2019

31 July 2019

12 October 2019

18 October 2019

15 December 2019

9 September 2020

8 February 2021

2 May 2021

2016

1 reference

page(s)

5474602

1 reference

Creative Commons Attribution 4.0 International

9 references

3 April 2019

25 June 2019

31 July 2019

12 October 2019

18 October 2019

15 December 2019

9 September 2020

8 February 2021

on focus list of Wikimedia project

2 May 2021

copyrighted

0 references

ScienceSource

0 references

cites work

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Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

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Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

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A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

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Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells

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Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

28 September 2017

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Versatile strategy for controlling the specificity and activity of engineered T cells

28 September 2017

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28 September 2017

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Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity.

28 September 2017

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28 September 2017

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Endogenous T-Cell Therapy: Clinical Experience

28 September 2017

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CAR T-cell immunotherapy: The path from the by-road to the freeway?

28 September 2017

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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

28 September 2017

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Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

28 September 2017

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Activated T cells armed with bispecific antibodies kill tumor targets

28 September 2017

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Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia

28 September 2017

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Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

28 September 2017

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Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

28 September 2017

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Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

28 September 2017

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Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies

28 September 2017

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28 September 2017

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Impact of a New Fusion Receptor on PD-1-Mediated Immunosuppression in Adoptive T Cell Therapy

28 September 2017

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TRUCKs: the fourth generation of CARs

28 September 2017

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Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment

28 September 2017

1 reference

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

28 September 2017

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Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling

28 September 2017

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Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases

28 September 2017

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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

28 September 2017

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Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

28 September 2017

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28 September 2017

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Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model

28 September 2017

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28 September 2017

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Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

28 September 2017

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Improving the safety of cell therapy products by suicide gene transfer

28 September 2017

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Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells

28 September 2017

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

28 September 2017

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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

28 September 2017

1 reference

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ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

28 September 2017

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Current concepts in the diagnosis and management of cytokine release syndrome

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Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition

28 September 2017

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CD28z CARs and armored CARs

28 September 2017

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

28 September 2017

1 reference

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Antibody-modified T cells: CARs take the front seat for hematologic malignancies

28 September 2017

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Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo

28 September 2017

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PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses

28 September 2017

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Design and development of therapies using chimeric antigen receptor-expressing T cells

28 September 2017

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Exploiting the curative potential of adoptive T-cell therapy for cancer

28 September 2017

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Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

28 September 2017

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TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

28 September 2017

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Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma

28 September 2017

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Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

28 September 2017

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Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity

28 September 2017

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B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma

28 September 2017

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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

28 September 2017

1 reference

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Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.

28 September 2017

1 reference

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Gene therapy for primary immunodeficiencies: Part 1.

28 September 2017

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CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.

28 September 2017

1 reference

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

28 September 2017

1 reference

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Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

28 September 2017

1 reference

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Th17 cells are long lived and retain a stem cell-like molecular signature

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

28 September 2017

1 reference

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Role of donor lymphocyte infusions in relapsed hematological malignancies after stem cell transplantation revisited

28 September 2017

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Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

28 September 2017

1 reference

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Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

28 September 2017

1 reference

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4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Treatment options for post-transplant lymphoproliferative disorder and other Epstein-Barr virus-associated malignancies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Genetically engineered T-cells for adoptive immunotherapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Targeting HER2 in other tumor types

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Non-MHC-dependent redirected T cells against tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Resistance of mature T cells to oncogene transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Perspective: assembly line immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F5474602

Transfer of chimeric receptor gene made of variable regions of tumor-specific antibody confers anticarbohydrate specificity on T cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889848

Are all chimeric antigen receptors created equal?

28 November 2018

1 reference

12 December 2020

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

1 reference

12 December 2020

Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

1 reference

12 December 2020

Genetic modification of T cells

1 reference

12 December 2020

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1 reference

12 December 2020

Identifiers

DOI

10.1155/2016/5474602

1 reference

release_cwy25nfd6rhatlhnctvbdyub2i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cwy25nfd6rhatlhnctvbdyub2i

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

27298832

1 reference