Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma (Q35598804)

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scientific article published on 23 March 2015

Language	Label	Description	Also known as
English	Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma	scientific article published on 23 March 2015

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scholarly article

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PubMed publication ID

9 August 2017

Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma (English)

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Cliona M Rooney

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Cliona M Rooney

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Malcolm Brenner

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Malcolm K Brenner

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Helen E Heslop

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Adrian Gee

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Enli Liu

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Zhuyong Mei

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Bambi Jo Grilley

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Bambi Grilley

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Gianpietro Dotti

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Gianpietro Dotti

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Jack Meng-Fen Su

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Meng-Fen Wu

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Stephen Gottschalk

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Stephen Gottschalk

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Olga Dakhova

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Claudia Gerken

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Meenakshi Hegde

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Meenakshi Hegde

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Winfried S Wels

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Winfried S Wels

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Vita S Brawley

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Alexia Ghazi

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Aidin Ashoori

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author name string

Nabil Ahmed

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Catherine Robertson

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Amanda Corder

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Tara Gray

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Hao Liu

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John Hicks

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Nino Rainusso

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Lisa L Wang

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Peter Anderson

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publication date

23 March 2015

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Journal of Clinical Oncology

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33

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1688-1696

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Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies

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PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses

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Design and development of therapies using chimeric antigen receptor-expressing T cells

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Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma.

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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

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12 July 2018

Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group

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Cellular immunotherapy for soft tissue sarcomas.

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Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma

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12 July 2018

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

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12 July 2018

Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases

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Inducible apoptosis as a safety switch for adoptive cell therapy

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12 July 2018

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

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12 July 2018

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

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12 July 2018

CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

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12 July 2018

Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.

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12 July 2018

Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

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12 July 2018

Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.

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12 July 2018

Improved Endpoints for Cancer Immunotherapy Trials

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12 July 2018

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

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12 July 2018

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

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12 July 2018

HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4429176

12 July 2018

Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.

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12 July 2018

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

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Bone tumors in adolescents and young adults

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12 July 2018

Lymphocyte numbers and subsets in the human blood. Do they mirror the situation in all organs?

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HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study

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New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

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Regression of experimental medulloblastoma following transfer of HER2-specific T cells

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Expression of HER2/erbB-2 correlates with survival in osteosarcoma

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Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

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Second and subsequent recurrences of osteosarcoma: presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patients

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Identifiers

10.1200/JCO.2014.58.0225

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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