Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects (Q26753082)

3 April 2019

25 June 2019

31 July 2019

19 September 2019

12 October 2019

18 October 2019

15 December 2019

1 August 2020

on focus list of Wikimedia project

8 February 2021

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CAR T cells for solid tumors: armed and ready to go?

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

7 April 2017

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T cell exclusion, immune privilege, and the tumor microenvironment

7 April 2017

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The future of immune checkpoint therapy

7 April 2017

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The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity

7 April 2017

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7 April 2017

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

7 April 2017

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Chimeric antigen receptor T cells for sustained remissions in leukemia

7 April 2017

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

7 April 2017

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

7 April 2017

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Natural Innate and Adaptive Immunity to Cancer

7 April 2017

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Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

7 April 2017

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

7 April 2017

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7 April 2017

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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

7 April 2017

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Stromal fibroblasts in cancer initiation and progression

7 April 2017

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Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

7 April 2017

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Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

7 April 2017

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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

28 September 2017

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Combination cancer immunotherapy and new immunomodulatory targets

28 September 2017

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28 September 2017

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

28 September 2017

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Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases

28 September 2017

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Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

28 September 2017

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Targeting cancer-specific mutations by T cell receptor gene therapy

28 September 2017

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Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy

28 September 2017

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T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

28 September 2017

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

28 September 2017

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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

28 September 2017

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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

28 September 2017

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

28 September 2017

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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

28 September 2017

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T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

28 September 2017

1 reference

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PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses

28 September 2017

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Antigen-specific in vitro expansion of functional redirected NY-ESO-1-specific human CD8+ T-cells in a cell-free system

28 September 2017

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Arming cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation".

28 September 2017

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Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells

28 September 2017

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Gene-engineered T cells for cancer therapy

28 September 2017

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TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

28 September 2017

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Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma

28 September 2017

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Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

28 September 2017

1 reference

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The basic principles of chimeric antigen receptor design

28 September 2017

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Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity

28 September 2017

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Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity

28 September 2017

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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

28 September 2017

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Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects

28 September 2017

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The convergence of radiation and immunogenic cell death signaling pathways.

28 September 2017

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Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group

28 September 2017

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A caspase 8-based suicide switch induces apoptosis in nanobody-directed chimeric receptor expressing T cells

28 September 2017

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Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

28 September 2017

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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

28 September 2017

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Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

28 September 2017

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Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

28 September 2017

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Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma

28 September 2017

1 reference

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Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

28 September 2017

1 reference

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TCR gene-engineered T cell: limited T cell activation and combined use of IL-15 and IL-21 ensure minimal differentiation and maximal antigen-specificity

28 September 2017

1 reference

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Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

28 September 2017

1 reference

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A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

28 September 2017

1 reference

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Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

28 September 2017

1 reference

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Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

28 September 2017

1 reference

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Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.

28 September 2017

1 reference

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T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.

28 September 2017

1 reference

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Immunogenic and tolerogenic cell death

28 September 2017

1 reference

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Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

The promise and potential pitfalls of chimeric antigen receptors

28 September 2017

1 reference

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The antitumor effects of CIK cells combined with docetaxel against drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo

28 September 2017

1 reference

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

28 September 2017

1 reference

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Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on immune enhancement

28 September 2017

1 reference

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IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Ecto-calreticulin in immunogenic chemotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Redirected activity of human antitumor chimeric immune receptors is governed by antigen and receptor expression levels and affinity of interaction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Tumor-derived chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Multidrug resistance-1 (MDR-1): a new target for T cell-based immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

T cell receptor-engineered T cells to treat solid tumors: T cell processing toward optimal T cell fitness

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Personal neoantigen cancer vaccines: The momentum builds

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4779545

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F3850839

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

21 January 2018

1 reference

12 December 2020

CD8⁺ cytotoxic T cell and FOXP3⁺ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

1 reference

12 December 2020

Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy

1 reference

12 December 2020

Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion

1 reference

12 December 2020

Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2

1 reference

12 December 2020

Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

1 reference

12 December 2020