Biochemical characterization of the core structure of alpha-synuclein filaments (Q30827075)

26 June 2017

title

Biochemical characterization of the core structure of alpha-synuclein filaments (English)

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26 June 2017

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Hirotomo Miake

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26 June 2017

Hidehiro Mizusawa

series ordinal

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26 June 2017

Takeshi Iwatsubo

series ordinal

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26 June 2017

Masato Hasegawa

series ordinal

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26 June 2017

language of work or name

English

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publication date

13 March 2002

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Journal of Biological Chemistry

26 June 2017

published in

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26 June 2017

volume

277

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26 June 2017

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26 June 2017

page(s)

19213-19219

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The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases

26 June 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M110551200

α-Synuclein in Lewy bodies

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Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

21 January 2018

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Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

21 January 2018

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Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

21 January 2018

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Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

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Widespread alterations of alpha-synuclein in multiple system atrophy

21 January 2018

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Synthetic filaments assembled from C-terminally truncated alpha-synuclein

21 January 2018

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Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain

21 January 2018

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Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

21 January 2018

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

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Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

21 January 2018

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Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

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Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

21 January 2018

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Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.

21 January 2018

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Identification of two distinct synucleins from human brain

21 January 2018

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Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

21 January 2018

1 reference

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110551200

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110551200

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110551200

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

21 January 2018

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Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M110551200

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26 June 2017

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