Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 (Q24313010)

GOA release 2020-03-11

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Bernardo L Sabatini

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David M. Sabatini

object named as

David M Sabatini

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author name string

Shuyu Wang

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Zhi-Yang Tsun

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Rachel L Wolfson

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Kuang Shen

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Gregory A Wyant

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Molly E Plovanich

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Elizabeth D Yuan

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Tony D Jones

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Lynne Chantranupong

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William Comb

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Tim Wang

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Liron Bar-Peled

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Christoph Straub

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Choah Kim

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Jiwon Park

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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language of work or name

English

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publication date

9 January 2015

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published in

Science

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volume

347

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issue

6218

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page(s)

188-94

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cites work

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

27 September 2017

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27 September 2017

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Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.1257132

Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.1257132

Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

21 January 2018

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Lysosomal pool of free-amino acids

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25567906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25567906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1257132

1 reference

1 reference

1 reference

PubMed publication ID

25567906

1 reference