Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. (Q37388792)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24174532%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity (English)

1 reference

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28 February 2020

0 references

1 reference

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28 February 2020

Min Li

1 reference

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28 February 2020

Bilon Khambu

1 reference

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28 February 2020

Hao Zhang

1 reference

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28 February 2020

Xiaoyun Chen

1 reference

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28 February 2020

Daohong Chen

1 reference

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28 February 2020

Laura Vollmer

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28 February 2020

Pei-Qing Liu

1 reference

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28 February 2020

Andreas Vogt

1 reference

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28 February 2020

Xiao-Ming Yin

1 reference

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28 February 2020

language of work or name

English

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publication date

30 October 2013

1 reference

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Journal of Biological Chemistry

28 February 2020

published in

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28 February 2020

volume

288

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28 February 2020

issue

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28 February 2020

page(s)

35769-35780

1 reference

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Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site

28 February 2020

cites work

1 reference

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Amino acid signalling upstream of mTOR

6 September 2017

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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

6 September 2017

1 reference

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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

6 September 2017

1 reference

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(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilization

6 September 2017

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

6 September 2017

1 reference

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

6 September 2017

1 reference

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

6 September 2017

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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

6 September 2017

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

6 September 2017

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Autophagy-regulating small molecules and their therapeutic applications

6 September 2017

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Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

6 September 2017

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Lysosomal function and dysfunction: mechanism and disease

6 September 2017

1 reference

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

6 September 2017

1 reference

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Regulation of TFEB and V-ATPases by mTORC1.

6 September 2017

1 reference

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TFEB links autophagy to lysosomal biogenesis

6 September 2017

1 reference

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Control of autophagy with small molecules

6 September 2017

1 reference

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Chemical modulators of autophagy as biological probes and potential therapeutics

6 September 2017

1 reference

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Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

6 September 2017

1 reference

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Eaten alive: a history of macroautophagy

6 September 2017

1 reference

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

6 September 2017

1 reference

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Termination of autophagy and reformation of lysosomes regulated by mTOR

6 September 2017

1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

6 September 2017

1 reference

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mTOR regulation of autophagy

6 September 2017

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Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

6 September 2017

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A role for ubiquitin in selective autophagy

6 September 2017

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Lysosomal membrane permeabilization in cell death

6 September 2017

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Regulation of TORC1 by Rag GTPases in nutrient response

6 September 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 September 2017

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Small molecule regulators of autophagy identified by an image-based high-throughput screen

6 September 2017

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The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

6 September 2017

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6 September 2017

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Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

6 September 2017

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Structure of Atg5.Atg16, a complex essential for autophagy

6 September 2017

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Autophagic stress in neuronal injury and disease.

6 September 2017

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

6 September 2017

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The role of autophagy during the early neonatal starvation period

6 September 2017

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Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

6 September 2017

1 reference

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Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice.

6 September 2017

1 reference

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Structure of the human mTOR complex I and its implications for rapamycin inhibition.

14 September 2017

1 reference

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Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: novel considerations.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3861628

Lysosomal positioning coordinates cellular nutrient responses.

26 June 2018

1 reference

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Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy

26 June 2018

1 reference

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Worm cure without tears. The effect of niclosamide on taeniasis saginata in man

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24174532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.511212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24174532%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24174532%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

24174532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24174532%20AND%20SRC:MED&resulttype=core&format=json