Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (Q24306785)

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English	Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3	scientific article

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scholarly article

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Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (English)

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Signal peptide peptidase like 2B

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GOA release 2020-03-11

Signal peptide peptidase like 3

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GOA release 2020-03-11

Histocompatibility minor 13

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GOA release 2020-03-11

protein homodimerization activity

1 reference

GOA release 2020-03-11

Histocompatibility (minor) 13

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GOA release 2020-03-11

Signal peptide peptidase-like 2

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GOA release 2020-03-11

Christian Haass

6

object named as

Christian Haass

author given names

Christian

author last names

Haass

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PubMed publication ID

9 December 2023

object named as

Peter Krawitz

1

author given names

Peter

author last names

Krawitz

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PubMed publication ID

9 December 2023

3

object named as

Regina Fluhrer

author given names

Regina

author last names

Fluhrer

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PubMed publication ID

9 December 2023

author name string

Christof Haffner

2

author given names

Christof

author last names

Haffner

1 reference

PubMed publication ID

9 December 2023

Harald Steiner

4

author given names

Harald

author last names

Steiner

1 reference

PubMed publication ID

9 December 2023

Bettina Schmid

5

author given names

Bettina

author last names

Schmid

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PubMed publication ID

9 December 2023

language of work or name

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publication date

25 November 2005

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Journal of Biological Chemistry

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280

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47

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39515-23

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Stages of embryonic development of the zebrafish

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

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Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

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7 January 2021

based on heuristic

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate.

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

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based on heuristic

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Signal sequences: more than just greasy peptides

1 reference

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Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

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Novel class of polytopic proteins with domains associated with putative protease activity

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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based on heuristic

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

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based on heuristic

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

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based on heuristic

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

1 reference

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based on heuristic

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Reconstitution of gamma-secretase activity

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based on heuristic

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

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Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

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A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

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The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

1 reference

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based on heuristic

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Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

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The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

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7 January 2021

based on heuristic

inferred from DOI database lookup

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

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https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two lysosomal membrane glycoproteins

1 reference

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based on heuristic

inferred from DOI database lookup

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramembrane proteolysis: theme and variations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

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