Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP (Q24294671)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

0 references

0 references

1 reference

GOA release 2020-03-11

WASP like actin nucleation promoting factor

1 reference

GOA release 2020-03-11

author name string

Hsin-Yi Henry Ho

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Marc W Kirschner

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Narayanaswamy Ramesh

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

language of work or name

English

0 references

publication date

1 June 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

29 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

page(s)

5269-5280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion

29 December 2019

cites work

1 reference

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WIP regulates N-WASP-mediated actin polymerization and filopodium formation

19 March 2017

1 reference

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Activation of Arp2/3 complex-mediated actin polymerization by cortactin

19 March 2017

1 reference

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A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

19 March 2017

1 reference

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Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex

19 March 2017

1 reference

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

19 March 2017

1 reference

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

19 March 2017

1 reference

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Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons

19 March 2017

1 reference

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19 March 2017

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Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER

19 March 2017

1 reference

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WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

19 March 2017

1 reference

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Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

19 March 2017

1 reference

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Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose

19 March 2017

1 reference

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Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

19 March 2017

1 reference

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Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage

19 March 2017

1 reference

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Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome

19 March 2017

1 reference

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Crystal structure of Arp2/3 complex

19 March 2017

1 reference

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Regulatory intramolecular association in a tyrosine kinase of the Tec family

19 March 2017

1 reference

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Cortactin: coupling membrane dynamics to cortical actin assembly

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

The immunological synapse: a molecular machine controlling T cell activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

19 March 2017

1 reference

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The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells

19 March 2017

1 reference

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Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth

19 March 2017

1 reference

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Identification of a ten-amino acid proline-rich SH3 binding site

19 March 2017

1 reference

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

19 March 2017

1 reference

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

19 March 2017

1 reference

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Dynamin2 and cortactin regulate actin assembly and filament organization.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

The Src-cortactin pathway is required for clustering of E-selectin and ICAM-1 in endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Flow cytometric determination of intracytoplasmic Wiskott-Aldrich syndrome protein in peripheral blood lymphocyte subpopulations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.

27 September 2017

1 reference

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Interaction of enteropathogenic or enterohemorrhagic Escherichia coli with HeLa cells results in translocation of cortactin to the bacterial adherence site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Identification and characterization of a novel cytoskeleton-associated pp60src substrate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Novel interaction of cortactin with endothelial cell myosin light chain kinase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Interaction of cortactin and N-WASp with Arp2/3 complex

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Ignition of a cellular machine

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Cortactin potentiates bone metastasis of breast cancer cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Human cortactin as putative cancer antigen

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Actin assembly mediated by Arp2/3 complex and WASP family proteins.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Tyrosine phosphorylation of cortactin associated with Syk accompanies thromboxane analogue-induced platelet shape change.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419870

Proteolysis of Platelet Cortactin by Calpain

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15169891

12 December 2020

inferred from PubMed ID database lookup

Tyrosine phosphorylation is required for actin-based motility of vaccinia but not Listeria or Shigella

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15169891

12 December 2020

inferred from PubMed ID database lookup

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15169891

12 December 2020

inferred from PubMed ID database lookup

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FMCB.24.12.5269-5280.2004

7 January 2021

inferred from DOI database lookup

Structure of the N-WASP EVH1 Domain-WIP Complex

1 reference

Crossref

https://api.crossref.org/works/10.1128%2FMCB.24.12.5269-5280.2004

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1128/MCB.24.12.5269-5280.2004

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

15169891

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15169891%20AND%20SRC:MED&resulttype=core&format=json