Structure of the N-WASP EVH1 Domain-WIP Complex (Q56567433)

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Kenneth E. Prehoda

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Jessica A. Scott

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Francis C. Peterson

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Wendell A. Lim

Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity

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language of work or name

English

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publication date

November 2002

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published in

Cell

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volume

111

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issue

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page(s)

565-576

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cites work

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The N-terminal domain of Homer/Vesl is a new class II EVH1 domain

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Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition

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EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family

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Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

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Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands

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Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

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GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

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Protein backbone angle restraints from searching a database for chemical shift and sequence homology

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

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WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia

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Wiskott-Aldrich syndrome in Argentina: 17 unique, including nine novel, mutations

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Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

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Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function

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7 January 2021

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

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7 January 2021

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

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7 January 2021

Identification of WASP mutations, mutation hotspots and genotype-phenotype disparities in 24 patients with the Wiskott-Aldrich syndrome

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Correlation of Backbone Amide and Aliphatic Side-Chain Resonances in 13C/15N-Enriched Proteins by Isotropic Mixing of 13C Magnetization

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Torsion angle dynamics for NMR structure calculation with the new program Dyana

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

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Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.

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7 January 2021

CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family

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7 January 2021

The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

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Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus

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MOLMOL: a program for display and analysis of macromolecular structures

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Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells

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7 January 2021

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

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7 January 2021

WIP regulates N-WASP-mediated actin polymerization and filopodium formation

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7 January 2021

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

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7 January 2021

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

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7 January 2021

The Wiskott-Aldrich syndrome protein (WASP) family

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7 January 2021

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

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7 January 2021

The WASp homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast

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7 January 2021

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

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7 January 2021

Molecular mechanisms controlling actin filament dynamics in nonmuscle cells

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Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

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7 January 2021

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

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7 January 2021

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

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7 January 2021

Pleckstrin homology domains: a common fold with diverse functions

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Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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7 January 2021

Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

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7 January 2021

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

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7 January 2021

Cutting edge: WIP, a binding partner for Wiskott-Aldrich syndrome protein, cooperates with Vav in the regulation of T cell activation

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7 January 2021

The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization

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7 January 2021

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

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7 January 2021

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

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7 January 2021

Protein-peptide interactions

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7 January 2021

Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

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7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

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7 January 2021

An optimized 3D NOESY-HSQC

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7 January 2021

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

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7 January 2021

X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene

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7 January 2021

The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

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7 January 2021

Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

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7 January 2021

Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome

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7 January 2021