A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42 (Q24670450)

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S Suetsugu

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H Miki

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K Fukami

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T Endo

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T Takenawa

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

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language of work or name

English

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publication date

5 February 2001

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published in

Journal of Cell Biology

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volume

152

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issue

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page(s)

471-82

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cites work

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The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42

7 April 2017

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

7 April 2017

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Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

7 April 2017

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WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

7 April 2017

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Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

7 April 2017

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

7 April 2017

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

7 April 2017

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

7 April 2017

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GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

7 April 2017

1 reference

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Identification of N-WASP homologs in human and rat brain

7 April 2017

1 reference

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Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation

7 April 2017

1 reference

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

7 April 2017

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

7 April 2017

1 reference

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Association of Ash/Grb-2 with dynamin through the Src homology 3 domain

7 April 2017

1 reference

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SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

7 April 2017

1 reference

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Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

7 April 2017

1 reference

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

7 April 2017

1 reference

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

7 April 2017

1 reference

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A presynaptic inositol-5-phosphatase

7 April 2017

1 reference

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Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms

7 April 2017

1 reference

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N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

The GTPase dynamin binds to and is activated by a subset of SH3 domains

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

7 April 2017

https://api.crossref.org/works/10.1083%2FJCB.152.3.471

7 January 2021

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Mechanism of Cdc42-induced actin polymerization in neutrophil extracts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

Isolation and characterization of a gamma-type phosphoinositide-specific phospholipase C (PLC-gamma 2).

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196001

G proteins and small GTPases: distant relatives keep in touch

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.152.3.471

Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11157975

12 December 2020

inferred from PubMed ID database lookup

Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11157975

12 December 2020

inferred from PubMed ID database lookup

Downregulated expression of the signaling molecules Nck, c-Crk, Grb2/Ash, PI 3-kinase p110 alpha and WRN during fibroblast aging in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11157975

12 December 2020