Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond (Q38129719)

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scientific article published on 17 August 2013

Language	Label	Description	Also known as
English	Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond	scientific article published on 17 August 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

5 references

3 April 2019

28 September 2019

27 November 2019

8 February 2021

28 October 2022

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond (English)

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

1 reference

3 April 2019

1 reference

28 September 2019

1 reference

27 November 2019

1 reference

8 February 2021

Matthias Hentze

2

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

author name string

Sven Danckwardt

1

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

Andreas E Kulozik

3

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

publication date

17 August 2013

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

1 November 2013

5 references

3 April 2019

28 September 2019

27 November 2019

8 February 2021

28 October 2022

Journal of Molecular Medicine

6 references

Europe PubMed Central

PMC publication ID

29 August 2017

3 April 2019

28 September 2019

27 November 2019

8 February 2021

28 October 2022

91

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

1257-1271

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

copyright license

Creative Commons Attribution-NonCommercial 2.0 Generic

17 August 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

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Twist is required for thrombin-induced tumor angiogenesis and growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

Does hypercoagulability awaken dormant tumor cells in the host?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

14 September 2017

Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

28 September 2017

Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

28 September 2017

In vitro release of vascular endothelial growth factor during platelet aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

28 September 2017

Thrombin in inflammation and healing: relevance to rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

28 September 2017

Thrombin induces the release of angiopoietin-1 from platelets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

A molecular mechanism for synapse elimination: novel inhibition of locally generated thrombin delays synapse loss in neonatal mouse muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Edema from intracerebral hemorrhage: the role of thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Prothrombin mRNA is expressed by cells of the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

23 June 2018

Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

The emerging role of splicing factors in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Progesterone and its metabolite allopregnanolone differentially regulate hemostatic proteins after traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Mature dendritic cells express functional thrombin receptors triggering chemotaxis and CCL18/pulmonary and activation-regulated chemokine induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Malignancies, prothrombotic mutations, and the risk of venous thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin, a mediator of neurotoxicity and memory impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Selective activation of thrombin is a critical determinant for vertebrate lens regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Rescue of prothrombin-deficiency by transgene expression in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Effect of thrombin inhibition in vascular dementia and silent cerebrovascular disease. An MR spectroscopy study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Regulation of prothrombin, thrombin receptor, and protease nexin-1 expression during development and after denervation in muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3825489

31 August 2018

Venous thromboembolism and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1074-5

21 January 2018

Clotting Factor Gene Polymorphisms and Colorectal Cancer Risk

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1074-5

21 January 2018

Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1074-5

21 January 2018

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1074-5

21 January 2018

Oral thrombostatin FM19 inhibits prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemostatic factors, innate immunity and malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombosis from a prothrombin mutation conveying antithrombin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in hemostasis in P-selectin-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 stimulates coagulation, not fibrinolysis, in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor-mediated increase of two matrix metalloproteinases, MMP-1 and MMP-3, in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways involved in thrombin-induced cell protection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of platelets in tumour angiogenesis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysis of tumor cells by natural killer cells in mice is impeded by platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin activates the growth, cell-cycle kinetics, and clustering of human dental pulp cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin Induces Proteinase-activated Receptor-1 Gene Expression in Endothelial Cells via Activation of Gi-linked Ras/Mitogen-activated Protein Kinase Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin activates Ras-CREB/ATF-1 signaling and stimulates c-fos, c-jun, and c-myc expression in human gingival fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the prothrombin gene and their association with plasma prothrombin levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Protease-Activated Receptor 1 Expression in Malignant Epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in hepatic mRNA expression of coagulant factors in type 2 diabetic model mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiation of proliferative events by human ?-thrombin requires both receptor binding and enzymic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deep-vein thrombosis and the incidence of subsequent symptomatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation of the hemostatic system during childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin enhances tumor cell adhesive and metastatic properties via increased alpha IIb beta 3 expression on the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin increases the metastatic potential of tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin receptor-mediated synovial proliferation in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumor tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-013-1074-5

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

Wikiquote(0 entries)

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