Prothrombin deficiency results in embryonic and neonatal lethality in mice (Q36500463)

14 August 2017

Prothrombin deficiency results in embryonic and neonatal lethality in mice (English)

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14 August 2017

T H Bugge

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14 August 2017

W Y Sun

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14 August 2017

D P Witte

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14 August 2017

J L Degen

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14 August 2017

M C Colbert

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14 August 2017

M C Burkart

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14 August 2017

K Holmbäck

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14 August 2017

Q Xiao

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14 August 2017

S J Degen

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14 August 2017

language of work or name

English

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publication date

1 June 1998

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Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

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14 August 2017

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14 August 2017

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14 August 2017

7597-7602

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Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Effect of tissue factor deficiency on mouse and tumor development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Protease-activated receptor 3 is a second thrombin receptor in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Platelet activation releases megakaryocyte-synthesized apolipoprotein J, a highly abundant protein in atheromatous lesions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Thrombin in inflammation and healing: relevance to rheumatoid arthritis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Role of the thrombin receptor in restenosis and atherosclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

The role of thrombin in tumor cell metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

The coagulation cascade: initiation, maintenance, and regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Biological consequences of thrombin receptor deficiency in mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

PCR Amplification from Paraffin-Embedded Tissues: Effects of Fixative and Fixation Time

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Role of tissue factor in embryonic blood vessel development.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

Role of the thrombin receptor in development and evidence for a second receptor.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22695

The role of thrombin and thrombin receptor activating peptide (TRAP-508) in initiation of tissue repair

21 September 2018

1 reference

12 December 2020

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction

1 reference

12 December 2020

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

1 reference

12 December 2020

Targeted disruption of the murine tissue factor gene results in embryonic lethality

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.13.7597

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14 August 2017

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14 August 2017

PubMed publication ID

9636195

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