Making new contacts: the mTOR network in metabolism and signalling crosstalk (Q38189969)

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scientific article published on March 2014

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English	Making new contacts: the mTOR network in metabolism and signalling crosstalk	scientific article published on March 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 August 2017

1 reference

Europe PubMed Central

Making new contacts: the mTOR network in metabolism and signalling crosstalk (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 August 2017

Mitsugu Shimobayashi

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Michael N Hall

2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

1 March 2014

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Europe PubMed Central

PubMed publication ID

30 August 2017

Nature Reviews Molecular Cell Biology

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

15

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

155-162

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24556838%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR signaling in growth control and disease

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Rheb binds and regulates the mTOR kinase

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR, translation initiation and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Amino acid signalling upstream of mTOR

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Tuberous sclerosis complex: linking cancer to metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Activation of mTORC2 by Association with the Ribosome

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

TOR complex 2: a signaling pathway of its own.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The translational landscape of mTOR signalling steers cancer initiation and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Distinct perturbation of the translatome by the antidiabetic drug metformin

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

A unifying model for mTORC1-mediated regulation of mRNA translation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR in aging, metabolism, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

A Central role for mTOR in lipid homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The multifaceted role of mTORC1 in the control of lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

DAP1, a novel substrate of mTOR, negatively regulates autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Termination of autophagy and reformation of lysosomes regulated by mTOR

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Regulation of TFEB and V-ATPases by mTORC1.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Elucidation of a universal size-control mechanism in Drosophila and mammals

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Lipid signalling in disease.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The complex world of WNT receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Notch signalling: a simple pathway becomes complex

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Where is mTOR and what is it doing there?

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Regulation of TORC1 by Rag GTPases in nutrient response

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Glutaminolysis activates Rag-mTORC1 signaling.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

Rapamycin passes the torch: a new generation of mTOR inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTOR kinase structure, mechanism and regulation

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FNRM3757

31 March 2020

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