Activation of mTORC2 by Association with the Ribosome (Q24294876)

DOI

https://api.crossref.org/works/10.1016/J.CELL.2011.02.014

26 November 2024

1 reference

Europe PubMed Central

PubMed publication ID

21376236

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21376236

26 November 2024

Michael N. Hall

1 reference

Europe PubMed Central

PubMed publication ID

21376236

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21376236

full work available at URL

26 November 2024

author name string

Vittoria Zinzalla

series ordinal

0 references

Daniele Stracka

series ordinal

0 references

Wolfgang Oppliger

series ordinal

0 references

language of work or name

English

0 references

publication date

4 March 2011

0 references

http://www.cell.com/article/S0092867411001280/pdf

file format

Portable Document Format

online access status

open access

1 reference

Europe PubMed Central

PubMed publication ID

21376236

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21376236

https://api.elsevier.com/content/article/PII:S0092867411001280?httpAccept=text/xml

26 November 2024

1 reference

DOI

https://api.crossref.org/works/10.1016/J.CELL.2011.02.014

https://api.elsevier.com/content/article/PII:S0092867411001280?httpAccept=text/plain

26 November 2024

1 reference

DOI

https://api.crossref.org/works/10.1016/J.CELL.2011.02.014

26 November 2024

0 references

144

0 references

issue

0 references

page(s)

757-68

0 references

cites work

Degradation of alpha-melanocyte stimulating hormone (alpha-MSH) by CALLA/endopeptidase 24.11 expressed by human melanoma cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Functional and therapeutic significance of Akt deregulation in malignant melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Eukaryotic ribosomes host PKC activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Emerging functions of ribosomal proteins in gene-specific transcription and translation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Concurrent blockade of the NF-kappaB and Akt pathways potently sensitizes cancer cells to chemotherapeutic-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

TOR signaling in invertebrates

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Functional specificity among ribosomal proteins regulates gene expression

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Regulation of ceramide biosynthesis by TOR complex 2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

How common are extraribosomal functions of ribosomal proteins?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Rheb fills a GAP between TSC and TOR.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

TOR complex 2: a signaling pathway of its own.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Expanding mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

TOR regulation of AGC kinases in yeast and mammals

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

PKCbetaII modulates translation independently from mTOR and through RACK1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

High density oligonucleotide array analysis of interferon- alpha2a sensitivity and transcriptional response in melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The fate of membrane-bound ribosomes following the termination of protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Molecular organization of target of rapamycin complex 2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Mutual antagonism of target of rapamycin and calcineurin signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

TOR1 and TOR2 have distinct locations in live cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Amino acid regulation of TOR complex 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Deregulated Akt3 activity promotes development of malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

The role of Myc-induced protein synthesis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

mTOR signaling at a glance

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.014

7 January 2021

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein

1 reference

https://api.crossref.org/works/10.1016/J.CELL.2011.02.014

Loss of PTEN promotes tumor development in malignant melanoma

26 November 2024

1 reference

https://api.crossref.org/works/10.1016/J.CELL.2011.02.014