The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. (Q35876952): Difference between revisions

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scientific article

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English	The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Steven H Bernstein

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Sundararajan Venkatesh

2

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Europe PubMed Central

PMC publication ID

10 August 2017

Min Li

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Jae Lee

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bin Lu

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Shannon P Hilchey

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Kimberly M Morse

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Hollie M Metcalfe

8

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Jolanta Skalska

9

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Michael Andreeff

10

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Paul S Brookes

11

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Carolyn K Suzuki

12

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

publication date

8 February 2012

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Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

119

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Europe PubMed Central

PMC publication ID

10 August 2017

14

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Europe PubMed Central

PMC publication ID

10 August 2017

3321-3329

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Europe PubMed Central

PMC publication ID

10 August 2017

Multitasking in the mitochondrion by the ATP-dependent Lon protease

1 reference

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Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

1 reference

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High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance

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Mantle cell lymphoma in relapse: the role of emerging new drugs.

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Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1.

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Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3

1 reference

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Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates

1 reference

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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

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Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma

1 reference

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27 July 2018

Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors.

1 reference

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

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Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance

1 reference

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

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27 July 2018

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore

1 reference

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27 July 2018

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

1 reference

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ER stress, hypoxia tolerance and tumor progression.

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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

1 reference

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2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis

1 reference

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

1 reference

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Cleavage site selection within a folded substrate by the ATP-dependent lon protease

1 reference

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Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death

1 reference

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The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals

1 reference

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Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathways

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Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

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A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma

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Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease

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Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration.

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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway

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Identifiers

10.1182/BLOOD-2011-02-340075

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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