Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (Q29616804)

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29 January 2020

review article

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title

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (English)

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30 April 2017

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29 January 2020

author

Dunyaporn Trachootham

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29 January 2020

Jerome Alexandre

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29 January 2020

Peng Huang

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29 January 2020

language of work or name

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30 April 2017

publication date

29 May 2009

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Nature Reviews Drug Discovery

29 January 2020

published in

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29 January 2020

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

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29 January 2020

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579-591

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

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31 March 2020

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Role of mitochondrial DNA in toxic responses to oxidative stress

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Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

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The role of p53 in base excision repair following genotoxic stress

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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

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The antioxidant function of the p53 tumor suppressor

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Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

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The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway

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Probing p53 biological functions through the use of genetically engineered mouse models

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p53 in health and disease

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p53 and its isoforms in cancer

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Inflammation and lung cancer: roles of reactive oxygen/nitrogen species

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Oxidative stress, redox, and the tumor microenvironment

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Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma

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The role of macrophage-derived TNFa in the induction of sublethal tumor cell DNA damage

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Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

31 March 2020

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Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells

31 March 2020

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Models of reactive oxygen species in cancer

31 March 2020

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Lipid peroxidation, free radical production and antioxidant status in breast cancer.

31 March 2020

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Antioxidant status and lipid peroxidation in colorectal cancer.

31 March 2020

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Antioxidant enzyme activities and the production of MDA and 8-oxo-dG in chronic lymphocytic leukemia

31 March 2020

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CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

31 March 2020

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Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Mechanisms of ROS modulated cell survival during carcinogenesis

31 March 2020

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

31 March 2020

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Reactive oxygen species in tumor metastasis

31 March 2020

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NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

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Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

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ROS as a tumour suppressor?

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Reactive oxygen species: a breath of life or death?

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Adaptation to oxidative stress: quinone-mediated protection of signaling in rat lung epithelial L2 cells

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Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

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Redox regulation and its emerging roles in stem cells and stem-like cancer cells

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Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

31 March 2020

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c-Myc phosphorylation is required for cellular response to oxidative stress

31 March 2020

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Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.

31 March 2020

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The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement

31 March 2020

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Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

31 March 2020

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The role of glutathione-S-transferase in anti-cancer drug resistance

31 March 2020

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31 March 2020

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Antioxidant inhibitors for cancer therapy.

31 March 2020

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31 March 2020

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Sensor/effector drug design with potential relevance to cancer

31 March 2020

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Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

31 March 2020

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Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

31 March 2020

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A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

31 March 2020

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Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide.

31 March 2020

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Bioenergetics and the formation of mitochondrial reactive oxygen species.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress.

31 March 2020

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Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.

31 March 2020

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Resistance to oxidants associated with elevated catalase activity in HL-60 leukemia cells that overexpress multidrug-resistance protein does not contribute to the resistance to daunorubicin manifested by these cells

31 March 2020

1 reference

Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo.

31 March 2020

1 reference

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

31 March 2020

1 reference

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

31 March 2020

1 reference

Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation

31 March 2020

1 reference

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

31 March 2020

1 reference

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

31 March 2020

1 reference

Oxidative stress and apoptosis: a new treatment paradigm in cancer.

31 March 2020

1 reference

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

31 March 2020

1 reference

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis

31 March 2020

1 reference

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

31 March 2020

1 reference

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

31 March 2020

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

31 March 2020

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

31 March 2020

1 reference

Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells

31 March 2020

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Novel aspects of oxidative stress-associated carcinogenesis

31 March 2020

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Oxidative stress in the regulation of normal and neoplastic hematopoiesis

31 March 2020

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The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

31 March 2020

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The role of oxygen availability in embryonic development and stem cell function

31 March 2020

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Cancer cell killing via ROS: to increase or decrease, that is the question

31 March 2020

1 reference

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

31 March 2020

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31 March 2020

The antioxidant paradox

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Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.

31 March 2020

1 reference

Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

31 March 2020

1 reference

Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients

31 March 2020

1 reference

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone

31 March 2020

1 reference

Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)

31 March 2020

1 reference

Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

31 March 2020

1 reference

Phase I trial of imexon in patients with advanced malignancy

31 March 2020

1 reference

Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.

31 March 2020

1 reference

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

31 March 2020

1 reference

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

31 March 2020

1 reference

Redox active disulfides: the thioredoxin system as a drug target

31 March 2020

1 reference

12 December 2020

Role of superoxide dismutase in cancer: a review

1 reference

12 December 2020

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

1 reference

12 December 2020

Production of large amounts of hydrogen peroxide by human tumor cells

1 reference

12 December 2020

Antioxidant enzyme levels in cancer

1 reference

12 December 2020

Gene expressions associated with chemosensitivity in human hepatoma cells.

1 reference

12 December 2020

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

1 reference

12 December 2020

Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients

1 reference

12 December 2020

Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization.

1 reference

12 December 2020

Experimental therapeutics: targeting the redox Achilles heel of cancer

1 reference

12 December 2020

Lipid peroxidation and antioxidant status in colorectal cancer

1 reference

12 December 2020

Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.

1 reference

12 December 2020

Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.

1 reference

12 December 2020

Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma

1 reference

12 December 2020

Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms

1 reference

12 December 2020

Antioxidant potential in esophageal, stomach and colorectal cancers.

1 reference

12 December 2020

Cellular redox status regulates hypoxia inducible factor-1 activity. Role in tumour development.

1 reference

12 December 2020

Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?

1 reference

12 December 2020

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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29 January 2020

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json