Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3 (Q34972949)

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English	Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3 (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Rehan Ahmad

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Deepak Raina

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Colin Meyer

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Donald Kufe

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

1 April 2008

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Europe PubMed Central

PubMed publication ID

5 August 2017

Cancer Research

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Europe PubMed Central

PubMed publication ID

5 August 2017

68

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Europe PubMed Central

PubMed publication ID

5 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2920-2926

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Study of protein targets for covalent modification by the antitumoral and anti-inflammatory prostaglandin PGA1: focus on vimentin

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Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective

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Touched and moved by STAT3.

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

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Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

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A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress.

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Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.

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The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance

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Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

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based on heuristic

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The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413761

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-07-3036

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Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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